Impact of smoking, COPD and comorbidities on the mortality of COVID-19 patients.
Impact of smoking, COPD and comorbidities on the mortality of COVID-19 patients.
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DOI：
10.1038/s41598-021-98749-4
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发表时间：
2021-09-28
影响因子：
4.6
通讯作者：
Resta O
中科院分区：
文献类型：
--
作者：
Lacedonia D;Scioscia G;Santomasi C;Fuso P;Carpagnano GE;Portacci A;Mastroianni F;Larizza G;Sabato E;Profilo E;Resta E;Foschino Barbaro MP;Resta O
2019冠状病毒病（COVID-19）患者的预后是可变的，取决于几个因素。目前有关慢性阻塞性肺病（COPD）和吸烟对COVID-19临床病程影响的数据仍然存在争议。本研究评估了因COVID-19肺炎导致呼吸衰竭而入住4个中间呼吸重症监护病房（普利亚，意大利）的521例COPD患者和吸烟者的患病率和预后。COPD和当前吸烟者的患病率分别为14%和13%。COPD患者的30天全因死亡率高于非COPD患者。与从不吸烟者和目前吸烟者相比，以前吸烟者的30天全因死亡率更高。COPD患者和既往吸烟者有更多的合并症。本研究描述了COVID-19患者同质队列中COPD患者和吸烟者的患病率和结局。该研究表明，COPD和当前吸烟者的患病率并不高，这表明他们感染的风险并没有增加。然而，当发生SARS-CoV-2感染时，COPD患者和既往吸烟者的全因死亡率最高，这似乎主要与合并症的存在有关，而与COPD和吸烟本身无关。
The prognosis of the coronavirus disease 2019 (COVID-19) patients is variable and depends on several factors. Current data about the impact of chronic obstructive pulmonary disease (COPD) and smoking on the clinical course of COVID-19 are still controversial. This study evaluated the prevalence and the prognosis of COPD patients and smokers in a cohort of 521 patients admitted to four intermediate Respiratory Intensive Care Units (Puglia, Italy) with respiratory failure due to COVID-19 pneumonia. The prevalence of COPD and current smokers was 14% and 13%, respectively. COPD patients had a higher 30-day all-cause mortality than non-COPD patients. Former smokers compared to never smokers and current smokers had higher 30-day all-cause mortality. COPD patients and former smokers had more comorbidities. This study described the prevalence and the outcomes of COPD patients and smokers in a homogenous cohort of COVID-19 patients. The study showed that the prevalence of COPD and current smokers was not high, suggesting that they were not at increased risk of getting the infection. However, when SARS-CoV-2 infection occurred, COPD patients and former smokers were those with the highest all-cause mortality, which seemed to be mainly related to the presence of comorbidities and not to COPD and smoking itself.
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影响因子：
2.3
作者：
Di Lecce V;Carpagnano GE;Pierucci P;Quaranta VN;Barratta F;Zito A;Buonamico E;Resta O
通讯作者：
Resta O
影响因子：
15.1
作者：
Gerayeli FV;Milne S;Cheung C;Li X;Yang CWT;Tam A;Choi LH;Bae A;Sin DD
通讯作者：
Sin DD
影响因子：
9.6
作者：
BONE, RC;BALK, RA
通讯作者：
BALK, RA
影响因子：
3.7
作者：
Guan WZ;Qiu GF;Feng-Liu
通讯作者：
Feng-Liu
DOI：
10.2147/copd.s276692
发表时间：
2020
影响因子：
2.8
作者：
Gómez Antúnez M;Muiño Míguez A;Bendala Estrada AD;Maestro de la Calle G;Monge Monge D;Boixeda R;Ena J;Mella Pérez C;Anton Santos JM;Lumbreras Bermejo C;SEMI-COVID-19 Network
通讯作者：
SEMI-COVID-19 Network