Event-related deep brain stimulation of the subthalamic nucleus affects conflict processing.
Event-related deep brain stimulation of the subthalamic nucleus affects conflict processing.
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DOI：
10.1002/ana.25312
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发表时间：
2018-10
影响因子：
11.2
通讯作者：
Chen R
中科院分区：
文献类型：
--
作者：
Ghahremani A;Aron AR;Udupa K;Saha U;Reddy D;Hutchison WD;Kalia SK;Hodaie M;Lozano AM;Chen R
许多证据表明，反应冲突调动了皮质-基底神经节系统中的大脑区域。在基底节区，来自丘脑底核（STN）的深部脑记录表明，冲突会触发低频振荡（LFO, 2-8Hz）的短暂增加。在这里，我们采用了一种新的方法，将短时间的事件相关脑深部刺激（DBS）传递到STN，以测试STN及其相关回路在冲突相关处理中的因果作用。在双盲设计中，我们通过在Stroop任务中锁定短暂的DBS序列来刺激帕金森病患者的STN。与非冲突试验相比，刺激在准备阶段的反应前阶段提供时，对冲突试验的反应相对加快（即减少Stroop效应，定义为冲突试验与非冲突试验之间的反应时间差异），对冲突试验具有特定的影响。在反应窗口的早期，刺激也会增加错误。这与在没有刺激的情况下观察到的冲突引起的LFO增加的时间一致，但与Stroop效应的减少没有直接关系。这些结果支持了从STN记录的LFO增加时间对应于冲突处理函数的理论。他们还提供了在认知控制范式中人类STN与事件相关的DBS的首次演示之一。
Many lines of evidence suggest that response conflict recruits brain regions in the cortical-basal ganglia system. Within the basal ganglia, deep brain recordings from the subthalamic nucleus (STN) have shown that conflict triggers a transient increase in low-frequency oscillations (LFO, 2–8Hz). Here, we deployed a new method of delivering short trains of event-related deep brain stimulation (DBS) to the STN to test the causal role of the STN and its associated circuits in conflict-related processing. In a double-blind design, we stimulated the STN in patients with Parkinson’s disease by locking brief trains of DBS to specific periods of the trial within a Stroop task. Stimulation had a specific effect on conflict compared to non-conflict trials by relatively speeding responses on conflict trials (i.e., reducing the Stroop effect, defined as the difference in reaction time between conflict and non-conflict trials) when it was delivered in the pre-response period in the preparation phase. Stimulation also increased errors when it was delivered early in the response window. This corresponded to the timing of conflict-induced increase in LFO observed in the absence of stimulation but was not directly related to the reduction in Stroop effect. These results support the theory that the time of LFO increase recorded from the STN corresponds to a conflict-processing function. They also provide one of the first demonstrations of event-related DBS of the STN in humans during a cognitive control paradigm.
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影响因子：
2.9
作者：
Liebrand M;Pein I;Tzvi E;Krämer UM
通讯作者：
Krämer UM
晚期帕金森病的自适应深脑刺激。
影响因子：
11.2
作者：
Little, Simon;Pogosyan, Alex;Neal, Spencer;Zavala, Baltazar;Zrinzo, Ludvic;Hariz, Marwan;Foltynie, Thomas;Limousin, Patricia;Ashkan, Keyoumars;FitzGerald, James;Green, Alexander L.;Aziz, Tipu Z.;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
3.4
作者：
Baunez, C;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
4.8
作者：
Keuken MC;Van Maanen L;Bogacz R;Schäfer A;Neumann J;Turner R;Forstmann BU
通讯作者：
Forstmann BU
DOI：
10.1016/j.cub.2016.01.051
发表时间：
2016-04-04
期刊：
Current biology : CB
影响因子：
--
作者：
Herz DM;Zavala BA;Bogacz R;Brown P
通讯作者：
Brown P