Respiratory syncytial virus disease burden in adults aged 60 years and older in high-income countries: A systematic literature review and meta-analysis.
Respiratory syncytial virus disease burden in adults aged 60 years and older in high-income countries: A systematic literature review and meta-analysis.
复制标题
DOI：
10.1111/irv.13031
复制
发表时间：
2023-01
影响因子：
4.4
通讯作者：
Pircon, Jean-Yves
中科院分区：
文献类型：
--
作者：
Savic, Miloje;Penders, Yolanda;Shi, Ting;Branche, Angela;Pircon, Jean-Yves
关键词：
呼吸道合胞病毒（RSV）相关的急性呼吸道感染（ARI）是老年人疾病的一个未被充分认识的原因。我们进行了一项系统性文献综述和Meta分析，以估计高收入国家≥60岁成人的RSV疾病负担。基于系统性文献检索，收集了美国、加拿大、欧洲国家、日本和韩国≥60岁成人的RSV‐ARI和住院发作率以及住院病死率（hCFR）数据（2000年1月1日至2021年11月3日）或通过其他方法（引文检索、既往Meta分析引用的未发表研究、灰色文献和RSV特异性摘要小册子）。对纳入研究的估计值进行了随机效应Meta分析。21项研究被纳入Meta分析。RSV‐ARI发作率的汇总估计值为1.62%（95%置信区间[CI]：0.84-3.08），住院发作率为0.15%（95% CI：0.09-0.22），hCFR为7.13%（95% CI：5.40-9.36）。到2019年，这将转化为高收入国家60岁以上成年人的约520万例病例、47万例住院和3.3万例住院死亡。在高收入国家，≥60岁成人的RSV疾病负担高于先前的估计，这突出表明该年龄组需要进行RSV预防。
Respiratory syncytial virus (RSV)‐associated acute respiratory infection (ARI) is an underrecognized cause of illness in older adults. We conducted a systematic literature review and meta‐analysis to estimate the RSV disease burden in adults ≥60 years in high‐income countries. Data on RSV‐ARI and hospitalization attack rates and in‐hospital case fatality rates (hCFR) in adults ≥60 years from the United States, Canada, European countries, Japan, and South Korea were collected based on a systematic literature search (January 1, 2000–November 3, 2021) or via other methods (citation search, unpublished studies cited by a previous meta‐analysis, gray literature, and an RSV‐specific abstract booklet). A random effects meta‐analysis was performed on estimates from the included studies. Twenty‐one studies were included in the meta‐analysis. The pooled estimates were 1.62% (95% confidence interval [CI]: 0.84–3.08) for RSV‐ARI attack rate, 0.15% (95% CI: 0.09–0.22) for hospitalization attack rate, and 7.13% (95% CI: 5.40–9.36) for hCFR. In 2019, this would translate into approximately 5.2 million cases, 470,000 hospitalizations, and 33,000 in‐hospital deaths in ≥60‐year‐old adults in high‐income countries. RSV disease burden in adults aged ≥60 years in high‐income countries is higher than previously estimated, highlighting the need for RSV prophylaxis in this age group.
登录
查看更多内容
影响因子：
28.2
作者：
HART, RJC
通讯作者：
HART, RJC
DOI：
10.1093/infdis/jit806
发表时间：
2014-06-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Fowlkes A;Giorgi A;Erdman D;Temte J;Goodin K;Di Lonardo S;Sun Y;Martin K;Feist M;Linz R;Boulton R;Bancroft E;McHugh L;Lojo J;Filbert K;Finelli L;IISP Working Group
通讯作者：
IISP Working Group
DOI：
10.1093/infdis/jit839
发表时间：
2014-06-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Falsey AR;McElhaney JE;Beran J;van Essen GA;Duval X;Esen M;Galtier F;Gervais P;Hwang SJ;Kremsner P;Launay O;Leroux-Roels G;McNeil SA;Nowakowski A;Richardus JH;Ruiz-Palacios G;St Rose S;Devaster JM;Oostvogels L;Durviaux S;Taylor S
通讯作者：
Taylor S
影响因子：
8.8
作者：
Allen, Kristen E.;Chommanard, Christina;Kim, Lindsay
通讯作者：
Kim, Lindsay
影响因子：
1.2
作者：
Beran, Jiri;Villaescusa, Ana Ramirez;Devaster, Jeanne-Marie
通讯作者：
Devaster, Jeanne-Marie