CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils.
CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils.
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DOI：
10.4049/jimmunol.0802808
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发表时间：
2009-04-01
期刊：
影响因子：
--
通讯作者：
Brown GD
中科院分区：
文献类型：
--
作者：
Kerrigan AM;Dennehy KM;Mourão-Sá D;Faro-Trindade I;Willment JA;Taylor PR;Eble JA;Reis e Sousa C;Brown GD
CLEC-2是c型凝集素样受体“Dectin-1簇”的成员，最初被认为仅限于血小板。在这里，我们证明小鼠的CLEC-2也通过外周血中性粒细胞表达，但仅通过骨髓或诱导的炎症中性粒细胞表达。在循环中性粒细胞中，CLEC-2可以介导抗体包被珠的吞噬和促炎细胞因子（包括TNFα）的产生，以响应CLEC-2配体红丝胞素。CLEC-2具有与Dectin-1相似的基于酪氨酸的细胞质基序，我们通过嵌合分析表明，该受体的活性依赖于酪氨酸。像Dectin-1一样，CLEC-2可以募集髓细胞中的信号激酶Syk，然而，刺激这一途径不会诱导呼吸爆发。因此，这些数据表明，clc -2的表达并不局限于血小板，它作为中性粒细胞的激活受体发挥作用。
CLEC-2 is a member of the ‘Dectin-1 cluster’ of C-type lectin-like receptors and was originally thought to be restricted to platelets. Here we demonstrate that murine CLEC-2 is also expressed by peripheral blood neutrophils, but only weakly by bone-marrow or elicited inflammatory neutrophils. On circulating neutrophils, CLEC-2 can mediate phagocytosis of antibody-coated beads and the production of proinflammatory cytokines, including TNFα, in response to the CLEC-2 ligand, rhodocytin. CLEC-2 possesses a tyrosine-based cytoplasmic motif similar to that of Dectin-1, and we show using chimeric analyses that the activities of this receptor are dependent on this tyrosine. Like Dectin-1, CLEC-2 can recruit the signalling kinase Syk in myeloid cells, however, stimulation of this pathway does not induce the respiratory burst. These data therefore demonstrate that CLEC-2 expression is not restricted to platelets and that it functions as an activation receptor on neutrophils.
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Dectin-1介导β-葡聚糖的生物学作用。
DOI：
10.1084/jem.20021890
发表时间：
2003-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brown GD;Herre J;Williams DL;Willment JA;Marshall AS;Gordon S
通讯作者：
Gordon S
DOI：
10.1042/bj20071216
发表时间：
2008-04-01
期刊：
The Biochemical journal
影响因子：
--
作者：
Christou CM;Pearce AC;Watson AA;Mistry AR;Pollitt AY;Fenton-May AE;Johnson LA;Jackson DG;Watson SP;O'Callaghan CA
通讯作者：
O'Callaghan CA
影响因子：
3.7
作者：
Peng, Hsin-Hsin;Liang, Shile;Dong, Cheng
通讯作者：
Dong, Cheng
影响因子：
5.4
作者：
Chaipan, Chawaree;Soilleux, Elizabeth J.;Poehlmann, Stefan
通讯作者：
Poehlmann, Stefan
影响因子：
20.3
作者：
Herre, J;Marshall, ASJ;Brown, GD
通讯作者：
Brown, GD