Analysis of the Effect of the TRPC4/TRPC5 Blocker, ML204, in Sucrose-Induced Metabolic Imbalance.
Analysis of the Effect of the TRPC4/TRPC5 Blocker, ML204, in Sucrose-Induced Metabolic Imbalance.
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DOI：
10.3390/ph16081100
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发表时间：
2023-08-03
期刊：
影响因子：
4.6
通讯作者：
Fernandes, Elizabeth S.
中科院分区：
文献类型：
--
作者：
Araujo, Mizael C.;Soczek, Suzany H. S.;Pontes, Jaqueline P.;Pinto, Bruno A. S.;Franca, Lucas M.;Soley, Bruna da Silva;Santos, Gabriela S.;Saminez, Warlison F. de Silva;Fernandes, Fernanda K. M.;Lima, Joao L. do Carmo;Maria-Ferreira, Daniele;Rodrigues, Joao F. S.;Quintao, Nara L. M.;Monteiro-Neto, Valerio;Paes, Antonio M. A.;Fernandes, Elizabeth S.
糖引起的代谢不平衡是一个主要的健康问题，因为在全球范围内，过量摄入碳水化合物与更高的肥胖率有关。蔗糖是一种由50%葡萄糖和50%果糖组成的二糖，通常用于食品工业，并存在于一系列快餐，餐馆和加工食品中。在此，我们研究了TRPC 4/TRPC 5阻断剂ML 204在小鼠早期暴露于富含蔗糖的饮食引发的代谢失衡中的作用。TRPC 4和TRPC 5属于非选择性Ca+2通道家族，称为瞬时受体电位通道。高蔗糖（HS）喂养的高血脂症和血脂异常的动物，伴随着体重指数增加。与正常饮食喂养的动物相比，肠系膜脂肪组织积聚，细胞直径更大，肝脏脂肪变性。HS小鼠还表现出脂肪、肝脏和胰腺TNFα和VEGF水平升高。ML 204可加重HS喂养小鼠的高脂血症、血脂异常、脂肪组织沉积、肝脂肪变性以及脂肪组织和肝脏TNFα。与接受载体的正常小鼠相比，接受阻断剂治疗的正常小鼠具有更大的肝脂肪变性和脂肪组织细胞数量/直径，但组织炎症、葡萄糖和脂质水平没有显着变化。结果表明TRPC 4/TRPC 5可以防止HS摄入引起的代谢失衡。
Sugar-induced metabolic imbalances are a major health problem since an excessive consumption of saccharides has been linked to greater obesity rates at a global level. Sucrose, a disaccharide composed of 50% glucose and 50% fructose, is commonly used in the food industry and found in a range of fast, restaurant, and processed foods. Herein, we investigated the effects of a TRPC4/TRPC5 blocker, ML204, in the metabolic imbalances triggered by early exposure to sucrose-enriched diet in mice. TRPC4 and TRPC5 belong to the family of non-selective Ca+2 channels known as transient receptor potential channels. High-sucrose (HS)-fed animals with hyperglycaemia and dyslipidaemia, were accompanied by increased body mass index. mesenteric adipose tissue accumulation with larger diameter cells and hepatic steatosis in comparison to those fed normal diet. HS mice also exhibited enhanced adipose, liver, and pancreas TNFα and VEGF levels. ML204 exacerbated hyperglycaemia, dyslipidaemia, fat tissue deposition, hepatic steatosis, and adipose tissue and liver TNFα in HS-fed mice. Normal mice treated with the blocker had greater hepatic steatosis and adipose tissue cell numbers/diameter than those receiving vehicle, but showed no significant changes in tissue inflammation, glucose, and lipid levels. The results indicate that TRPC4/TRPC5 protect against the metabolic imbalances caused by HS ingestion.
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影响因子：
6.5
作者：
Lian, Jihong;Watts, Russell;Lehner, Richard
通讯作者：
Lehner, Richard
影响因子：
4.5
作者：
Sousa RML;Ribeiro NLX;Pinto BAS;Sanches JR;da Silva MU;Coêlho CFF;França LM;de Figueiredo Neto JA;Paes AMA
通讯作者：
Paes AMA
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通讯作者：
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影响因子：
4.7
作者：
Kytikova OY;Novgorodtseva TP;Denisenko YK;Naumov DE;Gvozdenko TA;Perelman JM
通讯作者：
Perelman JM
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影响因子：
27.4
作者：
Alawi KM;Russell FA;Aubdool AA;Srivastava S;Riffo-Vasquez Y;Baldissera L Jr;Thakore P;Saleque N;Fernandes ES;Walsh DA;Brain SD
通讯作者：
Brain SD