Spinally delivered ampakine CX717 increases phrenic motor output in adult rats.
Spinally delivered ampakine CX717 increases phrenic motor output in adult rats.
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DOI：
10.1016/j.resp.2021.103814
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发表时间：
2022-03
影响因子：
2.3
通讯作者：
Fuller, David D.
中科院分区：
文献类型：
--
作者：
Thakre, Prajwal P.;Sunshine, Michael D.;Fuller, David D.
安帕金是一种合成分子，可以变构调节AMPA型谷氨酸受体。我们测试了向鞘内空间递送ampakines可以刺激膈肌的神经驱动的假设。通过放置在麻醉、机械通气的成年雄性Sprague-Dawley大鼠第四颈段鞘内空间中的导管递送Ampakine CX 717（20 mM，溶于10% HPCD中）或HPCD溶剂溶液。在给药后60分钟记录膈神经的电活动。鞘内应用CX 717产生膈吸气爆发振幅的逐渐和持续增加（n=10）。相比之下，应用HPCD（n=10）没有引起膈运动输出的持续变化。CX 717和HPCD处理的大鼠之间的膈爆发率、心率和平均动脉压相似。我们的结论是鞘内注射ampakines可以调节膈运动输出。这种方法可能有价值的有针对性的诱导脊髓神经可塑性的神经康复的背景下。
Ampakines are synthetic molecules that allosterically modulate AMPA-type glutamate receptors. We tested the hypothesis that delivery of ampakines to the intrathecal space could stimulate neural drive to the diaphragm. Ampakine CX717 (20mM, dissolved in 10% HPCD) or an HPCD vehicle solution were delivered via a catheter placed in the intrathecal space at the fourth cervical segment in urethane-anesthetized, mechanically ventilated adult male Sprague-Dawley rats. The electrical activity of the phrenic nerve was recorded for 60-minutes following drug application. Intrathecal application of CX717 produced a gradual and sustained increase in phrenic inspiratory burst amplitude (n=10). In contrast, application of HPCD (n=10) caused no sustained change in phrenic motor output. Phrenic burst rate, heart rate, and mean arterial pressure were similar between CX717 and HPCD treated rats. We conclude that intrathecally delivered ampakines can modulate phrenic motor output. This approach may have value for targeted induction of spinal neuroplasticity in the context of neurorehabiliation.
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DOI：
10.1016/s0034-5687(00)00124-9
发表时间：
2000-07-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Fuller, DD;Bach, KB;Mitchell, GS
通讯作者：
Mitchell, GS
影响因子：
4.2
作者：
Kucher, Klaus;Johns, Donald;Curt, Armin
通讯作者：
Curt, Armin
影响因子：
56.9
作者：
Minev, Ivan R.;Musienko, Pavel;Lacour, Stephanie P.
通讯作者：
Lacour, Stephanie P.
成年大鼠正常和病变的脊髓中的宫颈预性中间神经元。
影响因子：
2.5
作者：
Lane, Michael A.;White, Todd E.;Coutts, Marcella A.;Jones, Alex L.;Sandhu, Milapjit S.;Bloom, David C.;Bolser, Donald C.;Yates, Bill J.;Fuller, David D.;Reier, Paul J.
通讯作者：
Reier, Paul J.
影响因子：
2.3
作者：
Fuller, David D.;ElMallah, Mai K.;Smith, Barbara K.;Corti, Manuela;Lawson, Lee Ann;Falk, Darin J.;Byrne, Barry J.
通讯作者：
Byrne, Barry J.