Tissue damage-induced intestinal stem cell division in Drosophila.
Tissue damage-induced intestinal stem cell division in Drosophila.
复制标题
DOI：
10.1016/j.stem.2008.10.016
复制
发表时间：
2009-01-09
期刊：
影响因子：
23.9
通讯作者：
Ip YT
中科院分区：
文献类型：
--
作者：
Amcheslavsky A;Jiang J;Ip YT
干细胞分裂对于组织在生长、衰老和病原体攻击过程中的完整性至关重要。成年人胃肠道受到多种刺激，组织再生障碍可能导致炎症性疾病和癌症。最近已经鉴定出成年果蝇的肠干细胞，并显示其补充中肠内的各种细胞类型。然而，目前尚不清楚这些肠道干细胞是否能应对环境挑战。通过给果蝇喂食葡聚糖硫酸钠和博莱霉素并表达凋亡蛋白，我们表明果蝇肠道干细胞可以增加组织损伤时的分裂速率。此外，如果组织损伤导致上皮细胞损失，则新形成的成肠细胞可以分化成成熟的上皮细胞。通过使用这个新建立的肠干细胞增殖和组织再生系统，我们发现胰岛素受体信号通路是肠干细胞分裂所必需的。
Stem cell division is essential for tissue integrity during growth, aging, and pathogenic assaults. Adult gastrointestinal tract encounters numerous stimulations and impaired tissue regeneration may lead to inflammatory diseases and cancer. Intestinal stem cells in adult Drosophila have recently been identified and shown to replenish the various cell types within the midgut. However, it is not known whether these intestinal stem cells can respond to environmental challenges. By feeding dextran sulfate sodium and bleomycin to flies and by expressing apoptotic proteins, we show that Drosophila intestinal stem cells can increase the rate of division in response to tissue damage. Moreover, if tissue damage results in epithelial cell loss, the newly formed enteroblasts can differentiate into mature epithelial cells. By using this newly established system of intestinal stem cell proliferation and tissue regeneration, we find that the insulin receptor signaling pathway is required for intestinal stem cell division.
登录
查看更多内容
影响因子：
64.8
作者：
Clarkson, MJ;Wells, JRE;Tremethick, DJ
通讯作者：
Tremethick, DJ
影响因子：
64.5
作者：
Böhni, R;Riesgo-Escovar, J;Hafen, E
通讯作者：
Hafen, E
影响因子：
9.2
作者：
Brogiolo, W;Stocker, H;Hafen, E
通讯作者：
Hafen, E
影响因子：
2.7
作者：
Niemeyer, Philipp;Krause, Ulf;Mehlhorn, Alexander
通讯作者：
Mehlhorn, Alexander
影响因子：
23.9
作者：
Demidov, Oleg N.;Timofeev, Oleg;Bulavin, Dmitry V.
通讯作者：
Bulavin, Dmitry V.