Localization of c-MYB in differentiated cells during postnatal molar and alveolar bone development.

Localization of c-MYB in differentiated cells during postnatal molar and alveolar bone development.
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出生后磨牙和牙槽骨发育过程中 c-MYB 在分化细胞中的定位。

DOI:
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发表时间:
2012
影响因子:
1.9
通讯作者:
E. Matalova
E. Matalova
中科院分区:
医学4区
文献类型:
--
作者:
Vlasta Lungova;M. Buchtová;E. Janečková;A. Tucker;L. Knopfová;J. Šmarda;E. Matalova

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MYB家族的转录激活因子与许多组织中细胞的高增殖率和未分化状态有关。最近出现的数据表明,这些分子也可能在分化中发挥作用。在这项研究中,c-MYB的表达模式,随后在出生后阶段的小鼠磨牙牙的连续切片上使用免疫组化。沿着大量的c-MYB蛋白在增殖区,我们证实了这种蛋白在分化的成釉细胞,成牙本质细胞和成骨细胞中的存在。此外,c-MYB也见于成牙骨质细胞和肺泡成纤维细胞。这些发现表明,在硬组织分化和矿化过程中,c-MYB整合到调控网络中。
The MYB family of transcription activators has been associated with a high proliferation rate and an undifferentiated state of cells in a number of tissues. Recently emerging data suggest that these molecules may also play a role in differentiation. In this study, the pattern of expression of c-MYB was followed during postnatal stages of mouse molar odontogenesis using immunohistochemistry on serial sections. Along with an abundance of the c-MYB protein in proliferating zones, we confirmed the presence of this protein in differentiated ameloblasts, odontoblasts, and osteoblasts. In addition, c-MYB was also found in cementoblasts and alveolar fibroblasts. These findings suggest integration of c-MYB into regulatory networks during hard-tissue differentiation and mineralization.
DOI: --
发表时间: 2005
期刊: The Journal of biological chemistry
影响因子: --
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