Conductance-Based Determination of Solid-State Nanopore Size and Shape: An Exploration of Performance Limits.
Conductance-Based Determination of Solid-State Nanopore Size and Shape: An Exploration of Performance Limits.
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DOI：
10.1021/jp305381j
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发表时间：
2012-11-08
影响因子：
3.7
通讯作者：
Dwyer, Jason R.
中科院分区：
文献类型：
--
作者：
Frament, Cameron M.;Dwyer, Jason R.
纳米孔的大小和形状的知识是关键的许多实现这些单分子传感元件。通过拟合表面带电的固体纳米孔电导的电解质浓度依赖性来确定几何形状，已被提议取代要求苛刻的基于电子显微镜的方法。电导的功能形式限制了用于表征纳米孔的自由参数的数量，这对该方法提出了挑战。我们使用三个自由几何参数计算了具有指数圆柱形径向轮廓的纳米孔与电解质相关的电导；这种轮廓本身不能通过电导进行唯一的几何优化。然而，几种不同的结构简化模型与电导的定量一致，但对关键几何参数的估计误差超过40%。一个易于处理的锥形-圆柱形模型可以很好地表征纳米孔的大小和形状，其极限半径误差小于1%。了解这些性能限制为使用和扩展纳米孔电导分析模型提供了基础。
Knowledge of nanopore size and shape is critical for many implementations of these single-molecule sensing elements. Geometry determination by fitting the electrolyte-concentration-dependence of the conductance of surface-charged, solid-state nanopores has been proposed to replace demanding electron microscope-based methods. The functional form of the conductance poses challenges for this method by restricting the number of free parameters used to characterize the nanopore. We calculated the electrolyte-dependent conductance of nanopores with an exponential-cylindrical radial profile using three free geometric parameters; this profile, itself, could not be uniquely geometry-optimized by the conductance. Several different structurally simplified models, however, generated quantitative agreement with the conductance, but with errors exceeding 40% for estimates of key geometrical parameters. A tractable conical-cylindrical model afforded a good characterization of the nanopore size and shape, with errors of less than 1% for the limiting radius. Understanding these performance limits provides a basis for using and extending analytical nanopore conductance models.
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DOI：
10.1073/pnas.0911450106
发表时间：
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影响因子：
11.1
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