Intraocular Pressure Reduction by Femtosecond Laser Created Trabecular Channels in Perfused Human Anterior Segments.
Intraocular Pressure Reduction by Femtosecond Laser Created Trabecular Channels in Perfused Human Anterior Segments.
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DOI：
10.1167/tvst.10.9.22
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发表时间：
2021-08-02
影响因子：
3
通讯作者：
Juhasz T
中科院分区：
文献类型：
--
作者：
Mikula E;Holland G;Bradford S;Khazaeinezhad R;Srass H;Suarez C;Jester JV;Juhasz T
本研究探讨了使用飞秒激光小梁切开术（FLT）在灌注前段模型中创建穿过小梁网进入施莱姆管的开放通道以降低眼内压（IOP）的初步可行性。将人眼前节（12只眼）分配至治疗组（n = 6）或假治疗组（n = 6）。对两组进行灌注，直至记录到基线IOP，然后进行直接FLT治疗或假治疗。记录治疗前后眼压。我们使用光谱域光学相干层析成像和二次谐波成像来研究FLT通道。在FLT组中，与FLT前IOP相比，IOP显著平均降低22%（7.13 ± 2.95 mm Hg至5.34 ± 1.62 mm Hg; P < 0.05）。在对照组中，与假手术前IOP相比，假手术后IOP保持相对不变（6.39 ± 3.69 mm Hg至6.67 ± 4.12 mm Hg）。本研究的结果表明，FLT治疗可以显着降低灌注模型中的IOP，并可能为原发性开角型青光眼提供一种潜在的非侵入性治疗选择。研究使用飞秒激光光致破坏小梁网可能导致当前青光眼手术的临床相关替代方案。
This study investigated the initial feasibility of using femtosecond laser trabeculotomy (FLT) to create open channels through the trabecular meshwork into Schlemm's canal to lower intraocular pressure (IOP) in a perfused anterior segment model. Human anterior segments (12 eyes) were assigned to either treatment (n = 6) or sham treatment (n = 6) groups. Both groups were perfused until a baseline IOP was recorded upon which a direct FLT treatment or a sham treatment was administered. IOP was recorded before and after the treatment. Spectral domain optical coherence tomography and second harmonic generation imaging we used to investigate the FLT channels. In the FLT group, there was a significant mean decrease in the IOP of 22% compared with the pre-FLT IOP (7.13 ± 2.95 mm Hg to 5.34 ± 1.62 mm Hg; P < 0.05). In the control group, the post-sham IOP remained relatively unchanged compared with the pre-sham IOP (6.39 ± 3.69 mm Hg to 6.67 ± 4.12 mm Hg). The results of this study indicate that FLT treatment can significantly decrease the IOP in a perfusion model and may provide a potential noninvasive treatment option for primary open angle glaucoma. Investigating the use of femtosecond lasers for photodisrupting the trabecular meshwork can lead to a clinically relevant alternative to current glaucoma procedures.
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DOI：
10.1038/s41433-018-0148-6
发表时间：
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期刊：
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影响因子：
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发表时间：
1999-07-01
影响因子：
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DOI：
10.2147/opth.s152268
发表时间：
2018
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
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