A novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study.
A novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study.
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一种分析生活方式因素对胰腺癌风险综合影响的新型评分系统：回顾性病例对照研究
DOI：
10.1038/s41598-017-13182-w
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发表时间：
2017-10-20
影响因子：
4.6
通讯作者：
Cao L
中科院分区：
文献类型：
--
作者：
Pang T;Ding G;Wu Z;Jiang G;Yang Y;Zhang X;Cao L
虽然已经确定了胰腺导管腺癌（PDAC）发病的几个风险因素，但目前尚未建立系统评价PDAC风险的评分系统。本研究在1997年至2013年的17年间（包括1274例PDAC患者和3630例非癌症患者），对4904例PDAC患者进行了单中心研究，旨在建立一个新的评分系统，并评估PDAC患者危险因素的综合影响。对病例组和对照组进行系统的逻辑分析，并构建风险评级系统来评估联合危险因素。确定7个独立的危险因素与PDAC的危险性增加，被选入危险评分。建立了一个合并的风险评估模型，显示出显着增加的PDAC风险，在以下一些上升的分数。得分在1 ~ 4分以上的个体，OR（95% CI）分别为3.06（2.57~3.65）、7.08（5.63~8.91）、22.4（14.2~35.4）、31.4（12.7~77.5）。研究中基于整数的风险评分可用于风险分层，以在早期准确评估PDAC的发生。该评分系统提供了对PDAC风险的准确风险评估。
Although several risk factors for the onset of pancreatic ductal adenocarcinoma (PDAC) have been identified, currently, no scoring system to systemically evaluate the risk of PDAC has been established. In this study, we aimed to use a population of over 1200 patients to build a novel scoring system, and evaluated combined effects of risk factors for PDAC patients.A set of 4904 participants including 1274 PDAC patients and 3630 non-cancer individuals were recruited for the single-center study over 17-year period (1997~2013). Systematic logical analysis were presented for case and control groups, and a risk rating system was constructed to assess combined risk factors. Seven independent risk factors were identified with the increased risk of PDAC, were selected into the risk score. A merged risk assessment model was established, demonstrating significantly increased PDAC risk in following a number of rising scores. Individuals with scores from 1 to more than 4, the responding OR (95% CI) were 3.06 (2.57~3.65), 7.08 (5.63~8.91), 22.4 (14.2~35.4), and 31.4 (12.7~77.5), respectively. The integer-based risk score in the study can be used for risk stratification to accurately evaluate PDAC occurrence at an early stage. This scoring system provides an accurate risk assessment of PDAC risk.
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DOI：
10.1158/1940-6207.capr-12-0384
发表时间：
2013-04
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Odegaard AO;Koh WP;Yuan JM
通讯作者：
Yuan JM
影响因子：
9.8
作者：
Anderson, Michelle A.;Zolotarevsky, Eugene;Cooper, Kristine L.;Sherman, Simon;Shats, Oleg;Whitcomb, David C.;Lynch, Henry T.;Ghiorzo, Paola;Rubinstein, Wendy S.;Vogel, Kristen J.;Sasson, Aaron R.;Grizzle, William E.;Ketcham, Marsha A.;Lee, Shih-Yuan;Normolle, Daniel;Plonka, Caitlyn M.;Mertens, Amy N.;Tripon, Renee C.;Brand, Randall E.
通讯作者：
Brand, Randall E.
影响因子：
7.7
作者：
Mayerle, Julia;Hoffmeister, Albrecht;Moessner, Joachim
通讯作者：
Moessner, Joachim
通过外周血基因表达谱鉴定胰腺癌相关糖尿病的新型血液生物标志物
影响因子：
9.8
作者：
Huang, Hai;Dong, Xin;Wu, Yu Lian
通讯作者：
Wu, Yu Lian
影响因子：
5.8
作者：
Brodovicz, K. G.;Kou, T. D.;Goldstein, B. J.
通讯作者：
Goldstein, B. J.