Acquired fears reflected in cortical sensory processing: a review of electrophysiological studies of human classical conditioning.

Acquired fears reflected in cortical sensory processing: a review of electrophysiological studies of human classical conditioning.
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DOI:
10.1111/j.1469-8986.2012.01398.x
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发表时间:
2012-09
期刊:
影响因子:
3.7
通讯作者:
Keil A
Keil A
中科院分区:
心理学3区
文献类型:
--
作者:
Miskovic V;Keil A

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将中性刺激与情感价值相关联的能力是一种重要的生存策略,可以通过遵守赫布学习原则的细胞组装来实现。在神经科学实验室中,经典恐惧条件反射已被广泛用作研究学习相关的神经结构和功能变化的模型。在这里,我们回顾了经典的恐惧条件反射对人类电磁脑活动的影响,重点是感觉系统如何适应不断变化的恐惧相关的突发事件。通过考虑大规模神经元活动的时空模式,我们说明了一系列的皮层变化相关的神经元的敏感性,以放大信号与恐惧相关的刺激在其他感官信息的成本重新调整。假定的机制,可能是恐惧相关的可塑性在感觉皮层的水平进行了简要的考虑,并概述了未来工作的几种途径。
The capacity to associate neutral stimuli with affective value is an important survival strategy that can be accomplished by cell assemblies obeying Hebbian learning principles. In the neuroscience laboratory, classical fear conditioning has been extensively used as a model to study learning related changes in neural structure and function. Here, we review the effects of classical fear conditioning on electromagnetic brain activity in humans, focusing on how sensory systems adapt to changing fear-related contingencies. By considering spatio-temporal patterns of mass neuronal activity we illustrate a range of cortical changes related to a retuning of neuronal sensitivity to amplify signals consistent with fear-associated stimuli at the cost of other sensory information. Putative mechanisms that may underlie fear-associated plasticity at the level of the sensory cortices are briefly considered and several avenues for future work are outlined.
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