Effects of the Haemodynamic Stimulus on the Location of Carotid Plaques Based on a Patient-Specific Mechanobiological Plaque Atheroma Formation Model.
Effects of the Haemodynamic Stimulus on the Location of Carotid Plaques Based on a Patient-Specific Mechanobiological Plaque Atheroma Formation Model.
复制标题
血流动力学刺激对基于患者特异性机械生物学斑块组成模型的颈动脉斑块位置的影响。
DOI：
10.3389/fbioe.2021.690685
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发表时间：
2021
影响因子：
5.7
通讯作者：
Peña E
中科院分区：
文献类型：
--
作者：
Hernández-López P;Cilla M;Martínez M;Peña E
在这项工作中，我们提出了一个机械生物学动脉粥样硬化生长模型调制一个新的血液动力学刺激。为了测试这个模型，我们分析了30年来颈动脉分叉处动脉粥样硬化斑块的发展。特别是，八个几何形状（左或右颈动脉）从临床图像中分割，并与计算获得的解决方案进行比较，以验证模型。一些血液动力学刺激的斑块的位置和大小的影响进行了研究。使用时间平均壁面剪切应力（TAWSS），振荡剪切指数（OSI）和在这项工作中提出的一个新的指数的机械生物学模型预测的斑块进行了比较。新的指数预测的形状指数的内皮细胞的TAWSS和OSI值的组合，并使用来自文献的数据进行拟合。机械生物学模型代表了作者先前提出的模型的演变。该模型使用Navier-Stokes方程来模拟瞬态模式下沿管腔沿着的血流。它还采用达西定律和Kedem-Katchalsky方程的血浆和物质流通过内皮使用三孔模型。模型中考虑的所有物质的质量平衡均由对流-扩散-反应方程实现，最后计算了斑块的生长。结果表明，通过使用本研究中提出的新的机械刺激，在大多数情况下，斑块的预测优于仅使用TAWSS或OSI，狭窄率的最小和最大误差分别为2.77%和32.89%。然而，有一些几何形状，其中血液动力学不能预测斑块的位置，其他生物或遗传因素将比血液动力学更相关。特别是，该模型预测正确的14个斑块中的11个在所有考虑的几何形状。此外，已经计算了健康的几何形状，以检查在这种情况下模型没有形成斑块。
In this work, we propose a mechanobiological atheroma growth model modulated by a new haemodynamic stimulus. To test this model, we analyse the development of atheroma plaques in patient-specific bifurcations of carotid arteries for a total time of 30 years. In particular, eight geometries (left or right carotid arteries) were segmented from clinical images and compared with the solutions obtained computationally to validate the model. The influence of some haemodynamical stimuli on the location and size of plaques is also studied. Plaques predicted by the mechanobiological models using the time average wall shear stress (TAWSS), the oscillatory shear index (OSI) and a new index proposed in this work are compared. The new index predicts the shape index of the endothelial cells as a combination of TAWSS and OSI values and was fitted using data from the literature. The mechanobiological model represents an evolution of the one previously proposed by the authors. This model uses Navier-Stokes equations to simulate blood flow along the lumen in the transient mode. It also employs Darcy's law and Kedem-Katchalsky equations for plasma and substance flow across the endothelium using the three-pore model. The mass balances of all the substances that have been considered in the model are implemented by convection-diffusion-reaction equations, and finally the growth of the plaques has been computed. The results show that by using the new mechanical stimulus proposed in this study, prediction of plaques is, in most cases, better than only using TAWSS or OSI with a minimal and maximal errors on stenosis ratio of 2.77 and 32.89 %, respectively. However, there are a few geometries in which haemodynamics cannot predict the location of plaques, and other biological or genetic factors would be more relevant than haemodynamics. In particular, the model predicts correctly eleven of the fourteen plaques presented in all the geometries considered. Additionally, a healthy geometry has been computed to check that plaque is not developed with the model in this case.
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通过血管诊所中的计算模型对动脉粥样硬化的个性化管理：基于患者特定模拟方法的技术。
影响因子：
2.1
作者：
Díaz-Zuccarini V;Di Tomaso G;Agu O;Pichardo-Almarza C
通讯作者：
Pichardo-Almarza C
DOI：
10.1083/jcb.89.2.379
发表时间：
1981-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chamley-Campbell JH;Campbell GR;Ross R
通讯作者：
Ross R
影响因子：
3.2
作者：
Filipovic, Nenad;Teng, Zhongzhao;Parodi, Oberdan
通讯作者：
Parodi, Oberdan
影响因子：
3.9
作者：
Cilla, Myriam;Pena, Estefania;Martinez, Miguel A.
通讯作者：
Martinez, Miguel A.
影响因子：
15.9
作者：
BENNETT, MR;EVAN, GI;SCHWARTZ, SM
通讯作者：
SCHWARTZ, SM