Measurement of stiffness changes in immobilized muscle using magnetic resonance elastography.
Measurement of stiffness changes in immobilized muscle using magnetic resonance elastography.
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DOI：
10.1016/j.clinbiomech.2010.02.006
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
An KN
中科院分区：
文献类型：
--
作者：
Muraki T;Domire ZJ;McCullough MB;Chen Q;An KN
对肌肉在固定和废用后的变化进行单独评估是活体受试者面临的一个挑战。本研究的目的是确定磁共振弹性成像是否能够检测到这些变化。建立动物模型，以产生轻度关节挛缩后，42天的一个前肢固定在一个最大的屈曲位置，每天两次被动运动。取8对犬前肢。磁共振弹性成像扫描进行了实验肢体在一个扩展的肘部位置与扭矩为0.6 Nm。对侧肢体的扫描在两种条件下进行，位置匹配和扭矩匹配。此外，湿重，横截面积，静息肌长度，肘关节活动范围进行了测量。实验肢体的肌肉在肌肉质量、横截面积、松弛长度和肘关节活动范围方面表现出显著的减少。在位置匹配条件下比较肢体时，肌肉长度相似，实验侧肌肉的剪切模量（79.1（SD 12.0）kPa）显著高于对侧肌肉（31.9（SD 24.4）kPa）。在扭矩匹配条件下比较四肢时，肌肉应变相似，实验肌肉的剪切模量显著低于对侧肌肉（113.0（SD 24.8）kPa）。这些研究结果表明，制动后，磁共振弹性成像有可能被用作指导康复的临床工具，并作为一种研究工具，研究肌肉的被动弹性组件的损失。
The isolated evaluation of changes in muscle following immobilization and disuse is a challenge in living subjects. The purpose of this study was to determine whether magnetic resonance elastography is capable of detecting these changes. An animal model was created to produce a mild joint contracture following 42 days of one forelimb immobilization in a maximally flexed position with twice-daily passive exercise. Eight pairs of dog forelimbs were harvested. Magnetic resonance elastography scans were performed on the experimental limb in an extended elbow position with a torque of 0.6 Nm. Scans of the contralateral limb were performed in two conditions, position matching and torque matching. Furthermore, wet weight, cross sectional area, resting muscle length, and range of elbow joint motion were measured. The muscle from the experimental limb showed significant reduction in muscle mass, cross sectional area, slack length, and range of elbow motion. When comparing limbs in position matching condition, the muscle lengths were similar, and the experimental muscle had a significantly higher shear modulus (79.1 (SD 12.0) kPa) than the contralateral muscle (31.9 (SD 24.4) kPa). When comparing limbs in torque matching conditions, the muscle strains were similar, and the experimental muscle had a significantly lower shear modulus than the contralateral muscle (113.0 (SD 24.8) kPa). These findings suggest that following immobilization, magnetic resonance elastography has the potential to be used as a clinical tool to guide rehabilitation and as a research tool to study the loss of passive elastic components of muscle.
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影响因子：
3.3
作者：
BOOTH, FW
通讯作者：
BOOTH, FW
DOI：
10.1073/pnas.94.3.849
发表时间：
1997-02-04
影响因子：
11.1
作者：
Maniotis, AJ;Chen, CS;Ingber, DE
通讯作者：
Ingber, DE
影响因子：
--
作者：
Ramsey, RW;Street, SF
通讯作者：
Street, SF
影响因子：
56.9
作者：
MUTHUPILLAI, R;LOMAS, DJ;EHMAN, RL
通讯作者：
EHMAN, RL
影响因子：
3.2
作者：
Gajdosik, RL;Vander Linden, DW;Williams, AK
通讯作者：
Williams, AK