Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential.
Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential.
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人类dect骨自然杀伤细胞是具有免疫调节潜力的独特NK细胞子集。
DOI：
10.1084/jem.20030305
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发表时间：
2003-10-20
期刊：
影响因子：
--
通讯作者：
Strominger JL
中科院分区：
文献类型：
--
作者：
Koopman LA;Kopcow HD;Rybalov B;Boyson JE;Orange JS;Schatz F;Masch R;Lockwood CJ;Schachter AD;Park PJ;Strominger JL
自然杀伤细胞占人类早孕子宫蜕膜中淋巴细胞的50-90%。在这里，CD 56 bright子宫蜕膜NK（dNK）细胞与CD 56 bright和CD 56 dim外周NK细胞亚群进行了比较，通过流式细胞术和RT-PCR验证结果。在研究的10,000个基因中，当比较dNK和外周NK细胞亚群时，278个基因显示出至少三倍的变化，P ≤ 0.001，大多数在dNK细胞中显示出表达增加。这些编码的表面蛋白数量最多，包括不寻常的凝集素样受体NKG 2 E和Ly-49 L，几种杀伤细胞Ig样受体，整合素亚基αD，αX，β1和β5，以及多种四跨膜蛋白（CD 9，CD 151，CD 53，CD 63和TSPAN-5）。此外，已知具有免疫调节功能的两种分泌蛋白，半乳糖凝集素-1和孕激素相关蛋白14，在dNK细胞中选择性表达。
Natural killer cells constitute 50–90% of lymphocytes in human uterine decidua in early pregnancy. Here, CD56bright uterine decidual NK (dNK) cells were compared with the CD56bright and CD56dim peripheral NK cell subsets by microarray analysis, with verification of results by flow cytometry and RT-PCR. Among the ∼10,000 genes studied, 278 genes showed at least a threefold change with P ≤ 0.001 when comparing the dNK and peripheral NK cell subsets, most displaying increased expression in dNK cells. The largest number of these encoded surface proteins, including the unusual lectinlike receptors NKG2E and Ly-49L, several killer cell Ig-like receptors, the integrin subunits αD, αX, β1, and β5, and multiple tetraspanins (CD9, CD151, CD53, CD63, and TSPAN-5). Additionally, two secreted proteins, galectin-1 and progestagen-associated protein 14, known to have immunomodulatory functions, were selectively expressed in dNK cells.
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影响因子：
14.9
作者：
Baugh, L. R.;Hill, A. A.;Hunter, Craig P.
通讯作者：
Hunter, Craig P.
影响因子：
5.4
作者：
Carson, WE;Fehniger, TA;Caligiuri, MA
通讯作者：
Caligiuri, MA
影响因子：
3.2
作者：
Barten, R;Trowsdale, J
通讯作者：
Trowsdale, J
影响因子：
4.4
作者：
Campbell, JJ;Qin, SX;Butcher, EC
通讯作者：
Butcher, EC
影响因子：
64.8
作者：
Anderson, DM;Maraskovsky, E;Galibert, L
通讯作者：
Galibert, L