Synchrotron-based X-ray microscopic studies for bioeffects of nanomaterials.

Synchrotron-based X-ray microscopic studies for bioeffects of nanomaterials.
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基于同步加速器的 X 射线显微研究纳米材料的生物效应。

DOI:
10.1016/j.nano.2013.11.005
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发表时间:
2014-04
期刊:
影响因子:
5.5
通讯作者:
Fan, C
Fan, C
中科院分区:
医学3区
文献类型:
--
作者:
Li, J;Zhong, Z;Huang, Q;Fan, C

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纳米材料的生物学效应受到越来越多的关注,但由于纳米材料的纳米尺度和独特的化学性质,纳米材料的生物学效应研究面临着许多挑战。基于同步辐射的X射线显微镜是一种先进的成像技术,具有高空间分辨率和优异的元素特异性,为研究纳米材料与生命系统之间的相互作用提供了新的平台。本文综述了纳米材料在细胞、模式生物、动物和植物等生命系统中生物效应的X射线显微镜研究进展。我们的目的是提供一个概述的最先进的,和使用同步辐射为基础的X射线显微镜的characterizingin vitroandin vivo行为和生物分布的纳米材料的优点。我们还希望,新的同步加速器技术的组合使用应该提供前所未有的机会,更好地了解复杂的相互作用在纳米生物界面和会计纳米材料独特的生物效应。从临床编辑同步加速器为基础的X射线显微镜是一种非破坏性的成像技术,使高分辨率的金属元素水平的检测方法的空间映射。本文综述了这种新技术在纳米材料生物学和组织相互作用研究中的应用现状和前景。
There have been increasing interests in studying biological effects of nanomaterials, which are nevertheless faced up with many challenges due to the nanoscale dimensions and unique chemical properties of nanomaterials. Synchrotron-based X-ray microscopy, an advanced imaging technology with high spatial resolution and excellent elemental specificity, provides a new platform for studying interactions between nanomaterials and living systems. In this article, we review the recent progress of X-ray microscopic studies on bioeffects of nanomaterials in several living systems including cells, model organisms, animals and plants. We aim to provide an overview of the state of the art, and the advantages of using synchrotron-based X-ray microscopy for characterizingin vitroandin vivobehaviors and biodistribution of nanomaterials. We also expect that the use of a combination of new synchrotron techniques should offer unprecedented opportunities for better understanding complex interactions at the nano-biological interface and accounting for unique bioeffects of nanomaterials.From the Clinical EditorSynchrotron-based X-ray microscopy is a non-destructive imaging technique that enables high resolution spatial mapping of metals with elemental level detection methods. This review summarizes the current use and perspectives of this novel technique in studying the biology and tissue interactions of nanomaterials.
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