Synchrotron-based X-ray microscopic studies for bioeffects of nanomaterials.
Synchrotron-based X-ray microscopic studies for bioeffects of nanomaterials.
复制标题
基于同步加速器的 X 射线显微研究纳米材料的生物效应。
DOI:
10.1016/j.nano.2013.11.005
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发表时间:
2014-04
期刊:
影响因子:
5.5
通讯作者:
Fan, C
中科院分区:
文献类型:
--
作者:
Li, J;Zhong, Z;Huang, Q;Fan, C
There have been increasing interests in studying biological effects of nanomaterials, which are nevertheless faced up with many challenges due to the nanoscale dimensions and unique chemical properties of nanomaterials. Synchrotron-based X-ray microscopy, an advanced imaging technology with high spatial resolution and excellent elemental specificity, provides a new platform for studying interactions between nanomaterials and living systems. In this article, we review the recent progress of X-ray microscopic studies on bioeffects of nanomaterials in several living systems including cells, model organisms, animals and plants. We aim to provide an overview of the state of the art, and the advantages of using synchrotron-based X-ray microscopy for characterizingin vitroandin vivobehaviors and biodistribution of nanomaterials. We also expect that the use of a combination of new synchrotron techniques should offer unprecedented opportunities for better understanding complex interactions at the nano-biological interface and accounting for unique bioeffects of nanomaterials.From the Clinical EditorSynchrotron-based X-ray microscopy is a non-destructive imaging technique that enables high resolution spatial mapping of metals with elemental level detection methods. This review summarizes the current use and perspectives of this novel technique in studying the biology and tissue interactions of nanomaterials.
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影响因子:
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