Solvent signal as an NMR concentration reference.
Solvent signal as an NMR concentration reference.
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DOI：
10.1021/ac801938j
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发表时间：
2008-12-15
影响因子：
7.4
通讯作者：
Raftery, Daniel
中科院分区：
文献类型：
--
作者：
Huaping Mo;Raftery, Daniel
我们建议将 NMR 溶剂信号用作通用浓度参考，因为大多数溶剂可以通过 NMR 观察，并且可以轻松计算或独立确定溶剂浓度。特别是，高度质子化的溶剂（例如水）可以作为主要浓度标准品，因为其稳定性、可用性和易于观察。与强 NMR 信号相关的辐射阻尼的潜在问题可以通过小脉冲角激励来缓解。然后，NMR 接收器可以以与稀释分析物相同的效率检测溶剂信号。我们证明，以浓度超过 10 M 的溶剂（水）质子为参考，可以准确测定从 4 μM 到超过 100 M 的分析物质子浓度。所提出的方法稳健且对探针调谐无关，并且不需要任何额外的浓度标准。
We propose that the NMR solvent signal be utilized as a universal concentration reference because most solvents can be observed by NMR, and solvent concentrations can be readily calculated or determined independently. In particular, a highly protonated solvent such as water can serve as a primary concentration standard for its stability, availability and ease of observation. The potential issues of radiation damping associated with a strong NMR signal can be alleviated by small pulse angle excitations. The solvent signal then can be detected by the NMR receiver with the same efficiency as a dilute analyte. We demonstrated that the analyte's proton concentration can be accurately determined from 4 μM to more than 100 M, referenced by solvent (water) protons of concentrations more than 10 M. The proposed method is robust and indifferent to probe tuning, and does not require any additional concentration standard.
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影响因子：
7.4
作者：
Akoka, S;Barantin, L;Trierweiler, M
通讯作者：
Trierweiler, M
影响因子：
3.3
作者：
Gasparovic, Charles;Song, Tao;Morrison, Leslie A.
通讯作者：
Morrison, Leslie A.
DOI：
10.1006/jmrb.1994.1048
发表时间：
1994-05-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
OGG, RJ;KINGSLEY, PB;TAYLOR, JS
通讯作者：
TAYLOR, JS
影响因子：
4.3
作者：
Connell, MA;Davis, AL;Morris, GA
通讯作者：
Morris, GA
影响因子：
5.1
作者：
Pierens, Gregory K.;Carroll, Anthony R.;Quinn, Ronald J.
通讯作者：
Quinn, Ronald J.