Tumor metabolism and perfusion in head and neck squamous cell carcinoma: pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [18F]FDG-PET.
Tumor metabolism and perfusion in head and neck squamous cell carcinoma: pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [18F]FDG-PET.
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DOI：
10.1016/j.ijrobp.2010.11.022
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发表时间：
2012-01-01
影响因子：
7
通讯作者：
Shukla-Dave, Amita
中科院分区：
文献类型：
--
作者：
Jansen, Jacobus F. A.;Schoder, Heiko;Lee, Nancy Y.;Stambuk, Hilda. E.;Wang, Ya;Fury, Matthew G.;Patel, Snehal G.;Pfister, David G.;Shah, Jatin P.;Koutcher, Jason A.;Shukla-Dave, Amita
关键词：
将质子磁共振波谱（1H-MRS）、动态对比增强MRI（DCE-MRI）和18 F-氟脱氧葡萄糖（18F-FDG）正电子发射断层扫描（PET）在头颈部鳞状细胞癌（HNSCC）患者淋巴结转移中的相关性用于评估肿瘤生物学。此外，评价了治疗前多模态成像（MMI）预测短期治疗反应的有效性。对16例初治HNSCC患者治疗前进行1H-MRS、DCE-MRI和18F-FDG PET检查。在3-4个月时评价短期放射学反应。采用非参数斯皮尔曼秩相关分析法计算1H-MRS（胆碱浓度，Cho/W）、DCE-MRI（体积传递常数，Ktranss;血管外细胞外间隙体积分数，ve;再分布速率常数，kep）和18 F-FDG PET（标准摄取值，SUV;总病变糖酵解，TLG）之间的相关性。为了预测短期反应，进行逻辑回归分析。Cho/W与TLG呈显著正相关（ρ = 0.599，p = 0.031）。Cho/W与异质性指标std（ve）（ρ = −0.691，p = 0.004）和std（kep）（ρ = −0.704，p = 0.003）呈负相关。SUVmax值与MRI肿瘤体积密切相关（ρ = 0.643，p = 0.007）。Logistic回归分析显示，std（Ktranss）和SUV均值是近期疗效的显著预测因素（p < 0.07）。H-MRS、DCE-MRI和18F-FDG PET在治疗前对伴淋巴结转移的HNSCC患者进行多模态成像是可行的。此外，DCE-MRI和18F-FDG PET参数组合可预测短期治疗反应。
To correlate proton magnetic resonance spectroscopy (1H-MRS), dynamic contrast-enhanced MRI (DCE-MRI) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) in nodal metastases of patients with head and neck squamous cell carcinoma (HNSCC) for assessment of tumor biology. Additionally, pretreatment multimodality imaging (MMI) was evaluated for its efficacy in predicting short-term response to treatment. Metastatic neck nodes were imaged with 1H-MRS, DCE-MRI and 18F-FDG PET in 16 patients with newly diagnosed HNSCC before treatment. Short-term radiological response was evaluated at 3–4 months. The correlations between 1H-MRS (choline concentration, Cho/W), DCE-MRI (volume transfer constant, Ktrans; volume fraction of the extravascular extracellular space, ve; and redistribution rate constant, kep) and 18F-FDG PET (standard uptake value, SUV; and total lesion glycolysis, TLG) were calculated using non-parametric Spearman rank correlation. To predict the short-term response, logistic regression analysis was performed. A significant positive correlation was found between Cho/W and TLG (ρ = 0.599, p = 0.031). Cho/W correlated negatively with heterogeneity measures std(ve) (ρ = −0.691, p = 0.004) and std(kep) (ρ = −0.704, p = 0.003). SUVmax values correlated strongly with MRI tumor volume (ρ = 0.643, p = 0.007). Logistic regression indicated that std(Ktrans) and SUVmean were significant predictors of short-term response (p < 0.07). Pretreatment multi-modality imaging using 1H-MRS, DCE-MRI and 18F-FDG PET is feasible in HNSCC patients with nodal metastases. Additionally, combined DCE-MRI and 18F-FDG PET parameters were predictive of short-term response to treatment.
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影响因子：
45.3
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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DOI：
10.1016/j.ijrobp.2007.10.055
发表时间：
2008-07-01
影响因子：
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作者：
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通讯作者：
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DOI：
10.1186/1756-6649-9-4
发表时间：
2009-04-07
期刊：
BMC medical physics
影响因子：
--
作者：
Shukla-Dave, Amita;Lee, Nancy;Koutcher, Jason A
通讯作者：
Koutcher, Jason A