Dual Substance Use of Electronic Cigarettes and Alcohol.
Dual Substance Use of Electronic Cigarettes and Alcohol.
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DOI：
10.3389/fphys.2020.593803
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发表时间：
2020
影响因子：
4
通讯作者：
Wyatt TA
中科院分区：
文献类型：
--
作者：
Wetzel TJ;Wyatt TA
电子烟（EC）是一种现代尼古丁输送系统，在广泛使用中迅速增长，特别是在年轻人群中。鉴于酒精和尼古丁使用的长期共存历史，EC的流行率上升提出了关于其在酒精消费中的作用的问题。在众多型号的EC中，JUUL是最受欢迎的。本叙述性综述旨在确定EC和酒精双重使用之间关系的文献中的当前趋势，以及假设潜在的致病组织损伤和总结未来研究的领域，包括二手蒸汽暴露和呼吁研究之间的标准化。总之，EC用户更有可能参与危险饮酒，并且酒精使用障碍（AUD）的风险更高。我们推测，两用品的致病性损伤可能表现出叠加效应，特别是在肺部病原体清除、炎症增加和免疫反应降低、上皮细胞物理损伤以及慢性阻塞性肺病（COPD）样疾病加重方面。更好地了解致病性损害对于了解双重使用者暴露于呼吸道病原体（如严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2））时面临的风险至关重要。
Electronic cigarettes (ECs) are a modern nicotine delivery system that rapidly grew in widespread use, particularly in younger populations. Given the long history of the comorbidity of alcohol and nicotine use, the rising prevalence of ECs raises the question as to their role in the consumption of alcohol. Of the numerous models of ECs available, JUUL is the most popular. This narrative review aims to determine current trends in literature regarding the relationship between EC and alcohol dual use, as well as hypothesize potential pathogenic tissue damage and summarize areas for future study, including second-hand vapor exposure and calling for standardization among studies. In summary, EC users are more likely to participate in hazardous drinking and are at higher risk for alcohol use disorder (AUD). We surmise the pathogenic damage of dual use may exhibit an additive effect, particularly in pathogen clearance from the lungs, increased inflammation and decreased immune response, physical damage to epithelial cells, and exacerbation of chronic obstructive pulmonary disease (COPD)-like illnesses. A better understanding of pathogenic damages is critical to understand the risks placed on dual users when exposed to respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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影响因子：
4
作者：
Egleston BL;Meireles SI;Flieder DB;Clapper ML
通讯作者：
Clapper ML
影响因子：
4.4
作者：
Bush, Derek;Goniewicz, Maciej L.
通讯作者：
Goniewicz, Maciej L.
影响因子：
5.1
作者：
Gorukanti, Anuradha;Delucchi, Kevin;Halpern-Felsher, Bonnie
通讯作者：
Halpern-Felsher, Bonnie
影响因子：
10
作者：
Garcia-Arcos I;Geraghty P;Baumlin N;Campos M;Dabo AJ;Jundi B;Cummins N;Eden E;Grosche A;Salathe M;Foronjy R
通讯作者：
Foronjy R
影响因子：
3.3
作者：
Galvin, Jeffrey R.;Franks, Teri J.
通讯作者：
Franks, Teri J.