Sodium mapping in focal cerebral ischemia in the rat by quantitative (23)Na MRI.
Sodium mapping in focal cerebral ischemia in the rat by quantitative (23)Na MRI.
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DOI：
10.1002/jmri.21643
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发表时间：
2009-04
影响因子：
4.4
通讯作者：
Jones, Stephen C.
中科院分区：
文献类型：
--
作者：
Yushmanov, Victor E.;Yanovski, Boris;Kharlamov, Alexander;LaVerde, George;Boada, Fernando E.;Jones, Stephen C.
To validate 23Na twisted projection magnetic resonance imaging (MRI) as a quantitative technique to assess local brain sodium concentration ([Na+]br) during rat focal ischemia every 5.3 minutes. The MRI protocol included an ultrashort echo-time (0.4 msec), a correction of radiofrequency (RF) inhomogeneities by B1 mapping, and the use of 0–154 mM NaCl calibration standards. To compare MRI [Na+]br values with those obtained by emission flame photometry in precision-punched brain samples of about 0.5 mm3 size, MR images were aligned with a histological three-dimensional reconstruction of the punched brain and regions of interest (ROIs) were placed precisely over the punch voids. The Bland–Altman analysis of [Na+]br in normal and ischemic cortex and caudate putamen of seven rats quantitated by 23Na MRI and flame photometry yielded a mean bias and limits of agreement (at ±1.96 SD) of 2% and 43% of average, respectively. A linear increase in [Na+]br was observed between 1 and 6 hours after middle cerebral artery occlusion. 23Na MRI provides accurate and reliable results within the whole range of [Na+]br in ischemia with a temporal resolution of 5.3 minutes and precisely targeted submicroliter ROIs in selected brain structures.
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影响因子：
3.3
作者：
Yushmanov, Victor E.;Kharlamov, Alexander;Jones, Stephen C.
通讯作者：
Jones, Stephen C.
影响因子：
3.3
作者：
Christensen, JD;Barrere, BJ;Thulborn, KR
通讯作者：
Thulborn, KR
影响因子：
2.9
作者：
Hu, WX;Kharlamov, A;Jones, SC
通讯作者：
Jones, SC
影响因子：
3.3
作者：
Boada, FE;Gillen, JS;Thulborn, KR
通讯作者：
Thulborn, KR
影响因子：
8.3
作者：
Belayev, L;Alonso, OF;Ginsberg, MD
通讯作者：
Ginsberg, MD