Brain reactivity to emotional, neutral and cigarette-related stimuli in smokers.
Brain reactivity to emotional, neutral and cigarette-related stimuli in smokers.
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DOI：
10.1111/j.1369-1600.2010.00273.x
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发表时间：
2011-04
影响因子：
3.4
通讯作者：
Cinciripini PM
中科院分区：
文献类型：
--
作者：
Versace F;Minnix JA;Robinson JD;Lam CY;Brown VL;Cinciripini PM
成瘾被描述为通常参与情绪处理的神经机制的病理性篡夺。事件相关电位（ERP）可以提供与情绪相关刺激的处理相关的神经反应的非侵入性指标，并作为检查内在激励刺激和药物线索的处理之间的时间和空间共性的工具。在开始戒烟计划之前，116名吸烟者参加了一个实验室会议，在该会议中，记录了密集阵列ERP（129个传感器），在呈现具有情绪（愉快和不愉快），中性和与吸烟相关的内容的图片。使用随机化测试的时间区域的兴趣，通过时间主成分分析，分析ERP的类别之间的差异。在452-508毫秒的时间窗口内，情绪和情绪相关的图片比中央、顶叶和额叶网站的中性图片提示了更多的积极性。在212-316 ms的时间窗内，愉快和与之相关的图片都比中性图片引起更少的积极性。香烟相关的图片增强了P1成分的幅度（136-144毫秒）高于情绪和中性条件下测量的水平。这些结果支持了这一假设，即吸烟者，吸烟相关的线索是动机相关的刺激，捕获注意力资源早期在视觉处理和从事大脑回路通常参与处理内在的情绪刺激。
Addiction has been described as the pathological usurpation of the neural mechanisms normally involved in emotional processing. Event-related potentials (ERPs) can provide a noninvasive index of neural responses associated with the processing of emotionally relevant stimuli and serve as a tool for examining temporal and spatial commonalities between the processing of intrinsically motivating stimuli and drug cues. Before beginning a smoking cessation program, 116 smokers participated in a laboratory session in which dense-array ERPs (129 sensors) were recorded during the presentation of pictures with emotional (pleasant and unpleasant), neutral, and cigarette-related content. ERP differences among categories were analyzed with use of randomization tests on time regions of interest identified by temporal principal component analysis. Both emotional and cigarette-related pictures prompted significantly more positivity than did neutral pictures over central, parietal, and frontal sites in the 452–508 ms time window. During the 212–316 ms time window, both pleasant and cigarette-related pictures prompted less positivity than neutral images did. Cigarette-related pictures enhanced the amplitude of the P1 component (136–144 ms) above the levels measured in the emotional and neutral conditions. These results support the hypothesis that for smokers, cigarette-related cues are motivationally relevant stimuli that capture attentional resources early during visual processing and engage brain circuits normally involved in the processing of intrinsically emotional stimuli.
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影响因子：
3.7
作者：
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通讯作者：
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影响因子：
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