The Regulation of Germline Sex Determination in Drosophila by Sex lethal.
The Regulation of Germline Sex Determination in Drosophila by Sex lethal.
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DOI：
10.1159/000521235
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发表时间：
2022
影响因子：
2.3
通讯作者：
Van Doren, Mark
中科院分区：
文献类型：
--
作者：
Grmai, Lydia;Pozmanter, Caitlin;Van Doren, Mark
雄性或雌性身份的建立（性别决定）对于创造同一物种的两性之间的解剖学，生理学和行为差异（性二态性）至关重要。在许多生物中，包括哺乳动物和果蝇，性别是由性染色体的遗传决定的，而在其他动物中，性别是由环境因素决定的。可以说，性别决定最重要的结果是产生生殖所必需的健康配子：雌性卵母细胞和雄性精子细胞。精子和卵母细胞的产生需要性腺内两种不同细胞类型之间的合作：生殖细胞和体细胞。体细胞性腺或生殖细胞的性别决定缺陷导致性发育障碍和不育。在果蝇中，性致死基因（Sxl）是决定索马和生殖细胞性别的关键因素。然而，Sxl如何控制性别决定在索马中比在生殖系中更容易理解。本文将重点介绍生殖细胞中的Sxl：它如何在女性生殖细胞中特异性激活，以及它如何调节生殖细胞的性别决定和性发育。
The establishment of male or female identity (sex determination) is essential for creating the anatomical, physiological, and behavioral differences between two sexes of the same species (sexual dimorphism). In many organisms, including mammals and Drosophila, sex is determined by inheritance of sex chromosomes while, in other animals, sex is determined by environmental factors. Arguably the most important consequence of sex determination is the production of healthy gametes necessary for reproduction: female oocytes and male spermatids. Generation of sperm and oocytes requires cooperation between two different cell types within the gonad: germ cells and somatic cells. Defects in sex determination in either the somatic gonad or germline lead to Disorders of Sexual Development and infertility. In Drosophila, the gene Sex lethal (Sxl) is the key determinant of sex in both the soma and the germline. However, how Sxl controls sex determination is much more well understood in the soma than the germline. This review will focus on Sxl in the germline: how it is activated specifically in female germ cells and how it regulates germline sex determination and sexual development.
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影响因子：
3.7
作者：
Robida, Mark D.;Rahn, Andrew;Singh, Ravinder
通讯作者：
Singh, Ravinder
DOI：
10.1073/pnas.1319063110
发表时间：
2013-11-19
影响因子：
11.1
作者：
Evans, Daniel S.;Cline, Thomas W.
通讯作者：
Cline, Thomas W.
影响因子：
--
作者：
Gupta V;Parisi M;Sturgill D;Nuttall R;Doctolero M;Dudko OK;Malley JD;Eastman PS;Oliver B
通讯作者：
Oliver B
影响因子：
7
作者：
Li YR;Lai HW;Huang HH;Chen HC;Fugmann SD;Yang SY
通讯作者：
Yang SY
影响因子：
11.8
作者：
Decotto, E;Spradling, AC
通讯作者：
Spradling, AC