Stochastic models of cellular circadian rhythms in plants help to understand the impact of noise on robustness and clock structure.
Stochastic models of cellular circadian rhythms in plants help to understand the impact of noise on robustness and clock structure.
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DOI：
10.3389/fpls.2014.00564
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发表时间：
2014
影响因子：
5.6
通讯作者：
van Ooijen G
中科院分区：
文献类型：
--
作者：
Guerriero ML;Akman OE;van Ooijen G
节律行为对植物来说是必不可少的；例如，每日(昼夜)节律控制光合作用，季节节律控制它们的生命周期。生物钟的核心是一个基因网络，它以反映24小时昼夜循环的昼夜节律协调特定时钟基因的表达。由于时钟基因的低拷贝数和随之而来的细胞间差异，生物钟表现出随机噪声：这种内在噪声通过诱导更强劲的振荡行为在生物钟中发挥主要作用。另一个噪声源是环境，它会导致温度和光线强度的变化：这种外部噪声是时钟网络结构复杂性要求的一部分。实验技术的进步现在使单细胞测量和单细胞模型的发展成为可能。在这里，我们提供了一些模型研究，表明考虑这两种类型的噪声在理解植物如何适应规则和不规则的光变化方面的重要性。随机模型已被证明对理解规则变化的影响很有用。相比之下，对不规则变化的影响和不同噪声源的相互作用的研究较少。
Rhythmic behavior is essential for plants; for example, daily (circadian) rhythms control photosynthesis and seasonal rhythms regulate their life cycle. The core of the circadian clock is a genetic network that coordinates the expression of specific clock genes in a circadian rhythm reflecting the 24-h day/night cycle. Circadian clocks exhibit stochastic noise due to the low copy numbers of clock genes and the consequent cell-to-cell variation: this intrinsic noise plays a major role in circadian clocks by inducing more robust oscillatory behavior. Another source of noise is the environment, which causes variation in temperature and light intensity: this extrinsic noise is part of the requirement for the structural complexity of clock networks. Advances in experimental techniques now permit single-cell measurements and the development of single-cell models. Here we present some modeling studies showing the importance of considering both types of noise in understanding how plants adapt to regular and irregular light variations. Stochastic models have proven useful for understanding the effect of regular variations. By contrast, the impact of irregular variations and the interaction of different noise sources are less well studied.
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