Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: implications for evolution of the vertebrate disc.
Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: implications for evolution of the vertebrate disc.
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DOI：
10.1002/dvdy.23750
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发表时间：
2012-04
影响因子：
2.5
通讯作者：
Harfe, Brian D.
中科院分区：
文献类型：
--
作者：
Bruggeman, Bradley J.;Maier, Jennifer A.;Mohiuddin, Yasmin S.;Powers, Rae;Lo, Yinting;Guimaraes-Camboa, Nuno;Evans, Sylvia M.;Harfe, Brian D.
椎间盘的退化是衰老的不幸后果。哺乳动物的椎间盘由三个部分组成：一个被称为髓核的类神经节中心，软骨纤维环以及将椎间盘连接到椎骨的前后终板。为了了解椎间盘的起源，我们对鸡的椎间盘区域进行了研究。令人惊讶的是，我们对小鼠和鸡椎间盘的比较显示，鸡椎间盘缺乏髓核。此外，在小鼠中形成髓核的脊索被发现作为杆状结构持续存在，并在整个鸡胚胎发生过程中表达Shh。我们的命运映射数据表明，细胞起源于喙的一半，每个体节负责形成鸟类光盘，而细胞在尾部区域的每个体节形成椎骨。对哺乳动物和非哺乳动物的组织学分析表明，髓核仅存在于哺乳动物中。
Deterioration of the intervertebral discs is an unfortunate consequence of aging. The intervertebral disc in mammals is composed of three parts: a jelly-like center called the nucleus pulposus, the cartilaginous annulus fibrosus and anterior and posterior endplates that attach the discs to vertebrae. In order to understand the origin of the disc, we have investigated the intervertebral region of chickens. Surprisingly, our comparison of mouse and chicken discs revealed that chicken discs lack nuclei pulposi. In addition, the notochord, which in mice forms nuclei pulposi, was found to persist as a rod-like structure and express Shh throughout chicken embryogenesis. Our fate mapping data indicates that cells originating from the rostral half of each somite are responsible for forming the avian disc while cells in the caudal region of each somite form vertebrae. A histological analysis of mammalian and non-mammalian organisms suggests that nuclei pulposi are only present in mammals.
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影响因子：
2.5
作者：
Choi, Kyung-Suk;Cohn, Martin J.;Harfe, Brian D.
通讯作者：
Harfe, Brian D.
影响因子：
2.6
作者：
Kraus, F;Haenig, B;Kispert, A
通讯作者：
Kispert, A
影响因子：
64.8
作者：
Cai, Chen-Leng;Martin, Jody C.;Evans, Sylvia M.
通讯作者：
Evans, Sylvia M.
影响因子：
1.6
作者：
Kong, Min Ho;Do, Duc H.;Wang, Jeffrey C.
通讯作者：
Wang, Jeffrey C.
影响因子：
5.3
作者：
Katz, JN
通讯作者：
Katz, JN