The links between insulin resistance, diabetes, and cancer.
The links between insulin resistance, diabetes, and cancer.
复制标题
DOI：
10.1007/s11892-012-0356-6
复制
发表时间：
2013-04
影响因子：
4.2
通讯作者：
Mittelman, Steven D.
中科院分区：
文献类型：
--
作者：
Orgel, Etan;Mittelman, Steven D.
关键词：
肥胖症的日益流行导致多种相关疾病大幅增加。近期的证据强化了肥胖相关的胰岛素抵抗（IR）和/或糖尿病（DM）与癌症之间所提出的协同关系。在过去一年里，许多研究都对这种关系进行了探究。尽管确切的机制和途径尚不确定，但越来越清楚的是，高胰岛素血症以及可能持续的高血糖不仅是癌症发生的重要调节因素，也是治疗结果的重要调节因素。此外，随着我们对现有降糖药物的非代谢作用了解更多，有关糖尿病治疗选择的临床决策可能会受到影响。在我们的综述中，我们努力综合近期的文献，并简要阐述从宏观层面的临床关联到在细胞系和动物模型中正在阐明的具体机制关系的历程。
The growing epidemic of obesity has resulted in a large increase in multiple related diseases. Recent evidence has strengthened the proposed synergistic relationship between obesity-related insulin resistance (IR) and/or diabetes mellitus (DM) and cancer. Within the past year, many studies have examined this relationship. Although the precise mechanisms and pathways are uncertain, it is becoming clear that hyperinsulinemia and possibly sustained hyperglycemia are important regulators of not only the development of cancer but also of treatment outcome. Further, clinical decision-making regarding the treatment of choice for DM will likely be impacted as we learn more about the non-metabolic effects of the available hyperglycemic agents. In our review, we endeavored to synthesize the recent literature and provide a concise view of the journey from macro-level clinical associations to specific mechanistic relationships being elucidated in cell lines and animal models.
登录
查看更多内容
苯甲曲作为预防和乳腺癌异种移植的治疗。
影响因子：
8.8
作者：
Appleyard, M. V. C. L.;Murray, K. E.;Coates, P. J.;Wullschleger, S.;Bray, S. E.;Kernohan, N. M.;Fleming, S.;Alessi, D. R.;Thompson, A. M.
通讯作者：
Thompson, A. M.
影响因子：
5.8
作者：
Chang, Chia-Hsuin;Lin, Jou-Wei;Chuang, Lee-Ming
通讯作者：
Chuang, Lee-Ming
影响因子：
5
作者：
Coughlin, SS;Calle, EE;Thun, MJ
通讯作者：
Thun, MJ
DOI：
10.1158/1940-6207.capr-11-0299
发表时间：
2012-03
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Bao B;Wang Z;Ali S;Ahmad A;Azmi AS;Sarkar SH;Banerjee S;Kong D;Li Y;Thakur S;Sarkar FH
通讯作者：
Sarkar FH
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.