Generation COVID-19 - Should the foetus be worried?
Generation COVID-19 - Should the foetus be worried?
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DOI：
10.1111/apa.15693
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Austin T
中科院分区：
文献类型：
--
作者：
Iqbal A;Burrin C;Aydin E;Beardsall K;Wong H;Austin T
该叙述性审查的目的是评估COVID-19大流行对胎儿的直接和间接风险。直接和间接风险定义为：（a）垂直感染（先天性或产时），（B）母体感染及其后遗症，以及（c）封锁期间母体压力的来源，包括社会隔离和医疗保健提供的改变。早期的研究表明，垂直病毒传播是低的;然而，母亲感染可能对胎儿的生长和发育有重要影响。不同程度的封锁对准妈妈的健康、习惯和医疗服务的影响令人关切。特别是，母亲压力的增加已被证明对胎儿大脑发育有重大影响，增加了以后生活中心理健康以及认知和行为障碍的风险。根据迄今为止的证据，SARS-CoV-2病毒对胎儿的直接风险很低。这一流行病的间接影响，特别是产妇压力对发育中的大脑的影响，可能对这一代儿童产生终身的不利影响。
The aim of this narrative review was to evaluate the risks, both direct and indirect, to the foetus from the COVID‐19 pandemic. Direct and indirect risks were defined as (a) vertical infection (congenital or intrapartum), (b) maternal infection and its sequelae, and (c) sources of maternal stress during lockdown, including social isolation and altered healthcare provision. Early studies suggest that vertical viral transmission is low; however, there may be an important effect of maternal infection on foetal growth and development. The impact of various degrees of lockdown on prospective mothers’ health, habits and healthcare provision is of concern. In particular, increased maternal stress has been shown to have a significant effect on foetal brain development increasing the risk of mental health, and cognitive and behavioural disorders in later life. From the evidence available to date, direct risks to the foetus from the SARS‐CoV‐2 virus are low. Indirect effects of the pandemic, particularly resulting from the effect of maternal stress on the developing brain, can have lifelong detrimental impacts for this generation of children.
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