High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children.
High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children.
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DOI：
10.1016/j.psyneuen.2009.07.010
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发表时间：
2010-01
影响因子：
3.7
通讯作者：
Sandman, Curt A.
中科院分区：
文献类型：
--
作者：
Buss, Claudia;Davis, Elysia Poggi;Muftuler, L. Tugan;Head, Kevin;Sandman, Curt A.
因为大脑在胎儿发育期间经历了巨大的变化，所以它很容易受到环境的伤害。有证据表明，母亲在怀孕期间的压力和焦虑会影响出生结果，但没有研究评估人类怀孕期间的压力对大脑形态的影响。在目前的前瞻性纵向研究中，我们纳入了35名妇女，她们在妊娠19（±0.83）、25（±0.9）和31（±0.9）周时有妊娠焦虑的连续数据。当目标妊娠的后代在6到9岁之间时，他们的神经发育阶段通过结构MRI扫描进行评估。应用基于体素的形态测量学，我们发现在控制了总灰质体积、年龄、出生时胎龄、惯用手和产后感知压力后，灰质密度的区域性降低与妊娠焦虑相关。具体而言，独立于产后压力，妊娠19周时的妊娠焦虑与前额叶皮质、运动前皮质、内侧颞叶、外侧颞叶皮质、中央后回以及延伸至枕中回和梭状回的小脑的灰质体积减少相关。妊娠25周和31周时的高度妊娠焦虑与灰质体积的局部减少无显著相关性。这是第一项前瞻性研究，表明怀孕焦虑的特定时间模式与大脑形态的特定变化有关。受产前母亲焦虑影响的大脑区域的灰质体积改变可能使发育中的个体更容易受到神经发育和精神障碍以及认知和智力障碍的影响。
Because the brain undergoes dramatic changes during fetal development it is vulnerable to environmental insults. There is evidence that maternal stress and anxiety during pregnancy influences birth outcome but there are no studies that have evaluated the influence of stress during human pregnancy on brain morphology. In the current prospective longitudinal study we included 35 women for whom serial data on pregnancy anxiety was available at 19 (±0.83), 25 (±0.9) and 31 (±0.9) weeks gestation. When the offspring from the target pregnancy were between six to nine years of age, their neurodevelopmental stage was assessed by a structural MRI scan. With the application of voxel based morphometry, we found regional reductions in gray matter density in association with pregnancy anxiety after controlling for total gray matter volume, age, gestational age at birth, handedness and postpartum perceived stress. Specifically, independent of postnatal stress, pregnancy anxiety at 19 weeks gestation was associated with gray matter volume reductions in the prefrontal cortex, the premotor cortex, the medial temporal lobe, the lateral temporal cortex, the postcentral gyrus as well as the cerebellum extending to the middle occipital gyrus and the fusiform gyrus. High pregnancy anxiety at 25 and 31 weeks gestation was not significantly associated with local reductions in gray matter volume. This is the first prospective study to show that a specific temporal pattern of pregnancy anxiety is related to specific changes in brain morphology. Altered gray matter volume in brain regions affected by prenatal maternal anxiety may render the developing individual more vulnerable to neurodevelopmental and psychiatric disorders as well as cognitive and intellectual impairment.
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影响因子：
9.9
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Ahmad, Z;Balsamo, LM;Gaillard, WD
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