Gene amplification of c-myc and N-myc in small cell carcinoma of the lung.
Gene amplification of c-myc and N-myc in small cell carcinoma of the lung.
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小细胞肺癌中 c-myc 和 N-myc 的基因扩增。
DOI：
10.1126/science.3014659
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Vogelstein,B
中科院分区：
文献类型：
--
作者：
Wong,AJ;Ruppert,JM;Eggleston,J;Hamilton,SR;Baylin,SB;Vogelstein,B
研究了肺小细胞癌中c-myc和n -myc基因拷贝数与肿瘤形成和发展的关系。对来自45例患者的96个肿瘤病变进行了检查，这些病变可分为三类：高拷贝（每个单倍体基因组的N-mycor c-mycgene大于3个拷贝的肿瘤），中拷贝（每个基因组1.5至3个拷贝）和正常拷贝。14名患者有中拷贝肿瘤，但这几乎总是染色体复制的结果，而不是一个小的遗传位点的扩增。相比之下，5例患者有高拷贝肿瘤，由于基因扩增，每个病例的拷贝数都增加了。扩增并没有在个体患者中以异质方式发生，因为来自高拷贝肺肿瘤患者的所有转移灶也都是高拷贝，而来自其他患者的41个转移灶中没有一个是高拷贝。这些数据表明，基因扩增是一小部分肺小细胞癌患者肿瘤生长的重要步骤，并且该遗传事件在该亚群中发生相对较早（转移前）。
The relationship of the copy numbers of the c-mycand N-myconcogenes to tumor formation and progression was studied in small cell carcinoma of the lung. When 96 neoplastic lesions from 45 patients were examined, these lesions could be grouped into three categories: high copy (tumors with greater than 3 copies of the N-mycor c-mycgene per haploid genome), middle copy (1.5 to 3 copies per genome), and normal copy. Fourteen of the patients had middle copy tumors, but this was almost always a result of chromosome duplication rather than the amplification of a small genetic locus. In contrast, five patients had high copy tumors, with the increased copy number in each case due to gene amplification. The amplification did not occur in a heterogeneous fashion within individual patients, since all metastatic lesions from patients with high copy lung tumors were also high copy, while none of 41 metastatic lesions from the other patients were high copy. These data suggest that gene amplification is an important step in neoplastic growth in a subset of patients with small cell carcinoma of the lung and that this genetic event occurs relatively early (before metastasis) in this subset.
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