Assessment of protein disorder region predictions in CASP10.

Assessment of protein disorder region predictions in CASP10.
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DOI:
10.1002/prot.24391
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发表时间:
2014-02
影响因子:
2.9
通讯作者:
Fidelis, Krzysztof
Fidelis, Krzysztof
中科院分区:
生物学4区
文献类型:
--
作者:
Monastyrskyy, Bohdan;Kryshtafovych, Andriy;Moult, John;Tramontano, Anna;Fidelis, Krzysztof

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本文介绍了提交给CASP10的紊乱区预测的评估。评估是基于在以前的casp中测试的三个措施:(i)平衡精度,(ii)二元预测的马修斯相关系数,以及(iii)使用概率注释的预测的接收者工作特征(ROC)分析中的曲线下面积。我们还进行了新的分析,例如将提交的预测与Naïve疾病预测方法获得的预测以及与疾病预测数据库D2P2和MobiDB的预测进行比较。平均而言,参与CASP10的方法比参与CASP9的方法表现出略好的性能。
The article presents the assessment of disorder region predictions submitted to CASP10. The evaluation is based on the three measures tested in previous CASPs: (i) balanced accuracy, (ii) the Matthews correlation coefficient for the binary predictions, and (iii) the area under the curve in the receiver operating characteristic (ROC) analysis of predictions using probability annotation. We also performed new analyses such as comparison of the submitted predictions with those obtained with a Naïve disorder prediction method and with predictions from the disorder prediction databases D2P2 and MobiDB. On average, the methods participating in CASP10 demonstrated slightly better performance than those in CASP9.
DOI: 10.1002/prot.24399
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影响因子: 2.9
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