Cadmium-induced testicular injury.
Cadmium-induced testicular injury.
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DOI：
10.1016/j.taap.2009.01.028
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发表时间：
2009-08-01
影响因子：
3.8
通讯作者：
Cheng CY
中科院分区：
文献类型：
--
作者：
Siu ER;Mruk DD;Porto CS;Cheng CY
镉（Cd）是一种环境毒物和人体内分泌干扰物。几个器官（例如，肾脏、肝脏）受到镉的影响，最近的研究表明，睾丸对镉的毒性非常敏感。更重要的是，镉和其他有毒物质，如重金属（如，铅，汞）和基于雌激素的化合物（例如，双酚）可能是最近发达国家男性生育率下降的原因，因为它减少了精子数量和睾丸功能。在这篇综述中，我们批判性地讨论了该领域的最新数据表明，镉诱导的睾丸毒性可能是一个复杂的网络的原因相互作用的结果。这可能涉及通过特定的信号转导途径和信号分子（如p38丝裂原活化蛋白激酶（MAPK））破坏血睾丸屏障（BTB）。我们还总结了目前的研究，赋予睾丸对镉的敏感性的因素，如镉转运蛋白和金属硫蛋白，镉对睾丸的影响，作为一种内分泌干扰物，氧化应激诱导剂，以及它如何可能会破坏Zn+2和/或Ca+2介导的细胞事件。虽然需要大量的工作才能出现一个统一的机制途径镉诱导的睾丸毒性，最近的研究已经帮助确定一些可能的机制和/或事件发生在镉诱导的睾丸损伤。此外，最近的一些研究揭示了潜在的治疗或预防方法，可以在未来的研究中通过阻断或最大限度地减少镉对男性睾丸功能的破坏性影响来开发。
Cadmium (Cd) is an environmental toxicant and an endocrine disruptor in humans. Several organs (e.g., kidney, liver) are affected by Cd and recent studies have illustrated that the testis is exceedingly sensitive to Cd toxicity. More important, Cd and other toxicants, such as heavy metals (e.g., lead, mercury) and estrogenic-based compounds (e.g., bisphenols) may account for the recent declining fertility in men among developed countries by reducing sperm count and testis function. In this review, we critically discuss recent data in the field that have demonstrated the Cd-induced toxicity to the testis is probably the result of interactions of a complex network of causes. This is likely to involve the disruption of the blood-testis barrier (BTB) via specific signal transduction pathways and signaling molecules, such as p38 mitogen-activated protein kinase (MAPK). We also summarize current studies on factors that confer the testis sensitivity to Cd, such as Cd transporters and metallothioneins, and the impact of Cd on the testis as an endocrine disruptor, oxidative stress inducer and how it may disrupt the Zn+2 and/or Ca+2 mediated cellular events. While much work is needed before a unified mechanistic pathway of Cd-induced testicular toxicity is emerged, recent studies have helped to identify some of the likely mechanisms and/or events that take place during Cd-induced testis injury. Furthermore, some of the recent studies have shed lights on potential therapeutic or preventive approaches that can be developed in future studies by blocking or minimizing the destructive effects of Cd to testicular function in men.
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影响因子：
--
作者：
CHIQUOINE, A
通讯作者：
CHIQUOINE, A
影响因子：
3.3
作者：
Acharya, Usha R.;Mishra, Monalisa;Panda, Manoj K.
通讯作者：
Panda, Manoj K.
影响因子：
--
作者：
DE, SK;ENDERS, GC;ANDREWS, GK
通讯作者：
ANDREWS, GK
影响因子：
4.1
作者：
Brama, Marina;Gnessi, Lucio;Migliaccio, Silvia
通讯作者：
Migliaccio, Silvia
影响因子：
8.8
作者：
ROE, F J;DUKES, C E;CAMERON, K M;PUGH, R C;MITCHLEY, B C
通讯作者：
MITCHLEY, B C