Cortisol promotes the cognitive regulation of high intensive emotions independent of timing
Cortisol promotes the cognitive regulation of high intensive emotions independent of timing
复制标题
皮质醇促进高强度情绪的认知调节，与时间无关
DOI：
10.1111/ejn.15182
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发表时间：
--
影响因子：
3.4
通讯作者：
Jentsch
中科院分区：
文献类型：
--
作者：
Langer;Jentsch
未能认知地下调负面情绪是精神障碍的一个关键风险因素。先前的研究提供了证据，表明应激诱导的认知情绪调节改善可能通过糖皮质激素作用介导。皮质醇可以启动对认知控制功能的即时非基因组效应以及延迟的基因组效应，但其对情绪调节过程的独特影响仍有待证实。在这里，我们试图描述口服皮质醇对认知情绪调节结果的时间依赖性影响。我们期望皮质醇能提高情绪调节的成功率。皮质醇治疗和情绪调节，策略使用和强度的情绪刺激之间的延迟可能的相互作用进行了研究。85名健康男性在情绪调节范式之前30或90分钟接受10 mg氢化可的松或安慰剂，其中要求他们通过重新评价或分散注意力来下调他们对低强度和高强度负面图片的情绪反应。情感评级和瞳孔扩张作为结果的措施。减少唤醒，增强效价评级，以及增加瞳孔放大索引的认知调节努力表明成功下调高强度，但不是低强度的负面图片引起的负面情绪。皮质醇显着降低唤醒评级下调高强度的负面情绪时，通过分心和（在趋势水平），通过重新评估，独立的时间，表明皮质醇对主观调节结果的有益影响。总之，这项研究提供了初步的证据表明，皮质醇促进高强度的负面情绪的认知控制，治疗后30和90分钟。
Failures to cognitively downregulate negative emotions are a crucial risk factor for mental disorders. Previous studies provide evidence for a stress‐induced improvement of cognitive emotion regulation possibly mediated via glucocorticoid actions. Cortisol can initialize immediate non‐genomic as well as delayed genomic effects on cognitive control functioning, but its distinct effects on emotion regulation processes remain to be shown. Here, we sought to characterize time‐dependent effects of oral cortisol administration on cognitive emotion regulation outcomes. We expected cortisol to improve emotion regulation success. Possible interactions with the delay between cortisol treatment and emotion regulation, strategy use and intensity of the emotional stimuli were examined. Eighty‐five healthy men received either 10 mg hydrocortisone or a placebo in a double‐blind, randomized design 30 or 90 min prior to an emotion regulation paradigm, in which they were asked to downregulate their emotional responses towards low and high intensive negative pictures via reappraisal or distraction. Affective ratings and pupil dilation served as outcome measures. Reduced arousal, enhanced valence ratings as well as increases in pupil dilations indexing the cognitive regulatory effort indicated successful downregulation of negative emotions evoked by high intensive but not low intensive negative pictures. Cortisol significantly reduced arousal ratings when downregulating high intensive negative emotions via distraction and (at a trend level) via reappraisal, independent of timing, demonstrating a beneficial effect of cortisol on subjective regulatory outcomes. Taken together, this study provides initial evidence suggesting that cortisol promotes the cognitive control of high intensive negative emotions both, 30 and 90 min after treatment.
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影响因子：
3.3
作者：
Het, Serkan;Schoofs, Daniela;Wolf, Oliver T.
通讯作者：
Wolf, Oliver T.
影响因子：
4.6
作者：
Langer, Katja;Hagedorn, Bianca;Jentsch, Valerie L.
通讯作者：
Jentsch, Valerie L.
影响因子：
3.7
作者：
Kinner, Valerie L.;Kuchinke, Lars;Wolf, Oliver T.
通讯作者：
Wolf, Oliver T.
情绪调节：探索压力和性别的影响。
影响因子：
3
作者：
Kinner VL;Het S;Wolf OT
通讯作者：
Wolf OT
影响因子：
4.2
作者：
Schoenfelder, Sandra;Kanske, Philipp;Wessa, Michele
通讯作者：
Wessa, Michele