Innate immunity and chronic obstructive pulmonary disease: a mini-review.
Innate immunity and chronic obstructive pulmonary disease: a mini-review.
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DOI：
10.1159/000354173
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发表时间：
2013
期刊：
影响因子：
3.5
通讯作者：
Crystal RG
中科院分区：
文献类型：
--
作者：
Shaykhiev R;Crystal RG
慢性阻塞性肺疾病（COPD）是一种主要的吸烟相关的肺部疾病，其特征在于进行性不可逆的气流限制，影响全球超过2亿人。COPD患者对呼吸道感染的易感性增加，导致疾病加重。越来越多的证据表明，多种宿主防御机制，如由气道上皮屏障和先天免疫细胞（包括肺泡巨噬细胞、中性粒细胞、树突状细胞和自然杀伤细胞）提供的防御机制，在COPD中以吸烟依赖性方式被广泛抑制。在COPD吸烟者中观察到的先天免疫系统失活与衰老相关的免疫衰老表型非常相似。由于先天免疫防御缺陷，COPD吸烟者的肺部经常定植有病原体，通常会发生细菌和病毒感染，导致继发性炎症，这是疾病进展的主要驱动因素。在这篇综述中，我们总结了与COPD先天免疫系统紊乱相关的人类研究证据，讨论了这些变化与衰老之间的可能关系，并提供了旨在通过正常化先天免疫机制来预防COPD进展的潜在治疗策略的见解。
Chronic obstructive pulmonary disease (COPD), a major smoking-associated lung disorder characterized by progressive irreversible airflow limitation, affects > 200 million people worldwide. Individuals with COPD have increased susceptibility to respiratory infections, resulting in exacerbations of the disease. A growing body of evidence indicates that multiple host defense mechanisms, such as those provided by the airway epithelial barrier and innate immune cells, including alveolar macrophages, neutrophils, dendritic cells and natural killer cells, are broadly suppressed in COPD in a smoking-dependent manner. Inactivation of the innate immune system observed in COPD smokers is remarkably similar to the immunosenescence phenotype associated with aging. As a consequence of defective innate immune defense, the lungs of COPD smokers are frequently colonized with pathogens and commonly develop bacterial and viral infections, which cause secondary inflammation, a major driver of the disease progression. In this review, we summarize the evidence from human studies related to disordering of the innate immune system in COPD, discuss possible relationships between those changes and aging, and provide insights into potential therapeutic strategies aimed at the prevention of COPD progression via normalization of the disordered innate immune mechanisms.
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