Indoor dampness and molds and development of adult-onset asthma: a population-based incident case-control study.
Indoor dampness and molds and development of adult-onset asthma: a population-based incident case-control study.
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DOI：
10.1289/ehp.02110543
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发表时间：
2002-05
影响因子：
10.4
通讯作者：
Jaakkola JJ
中科院分区：
文献类型：
--
作者：
Jaakkola MS;Nordman H;Piipari R;Uitti J;Laitinen J;Karjalainen A;Hahtola P;Jaakkola JJ
以前的横断面和流行的病例对照研究表明，成人哮喘的风险增加与家中的潮湿问题和霉菌有关。我们进行了一项以人群为基础的事件病例对照研究，以评估工作场所和家中室内潮湿问题和霉菌对成人哮喘发展的影响。我们系统地招募了在2.5年的研究期间（1997-2000年）的所有新发哮喘病例，并从南芬兰皮尔坎马医院区21-63岁的成年人组成的源人群中随机选择对照。临床诊断的病例系列包括521例新诊断的哮喘成人和932例对照组，排除了76例（7.5%）有哮喘史的对照组。在调整混杂因素的logistic回归分析中，哮喘的风险与工作场所可见霉菌和/或霉菌气味的存在有关（比值比，1.54; 95%置信区间，1.01-2.32），但与水损害或潮湿污渍无关。我们估计，在暴露者中，归因于工作场所霉菌暴露的哮喘比例为35.1%（95%置信区间，1.0-56.9%）。目前的研究结果提供了新的证据，工作场所暴露于室内霉菌和成人发作的哮喘之间的关系。
Previous cross-sectional and prevalent case-control studies have suggested increased risk of asthma in adults related to dampness problems and molds in homes. We conducted a population-based incident case-control study to assess the effects of indoor dampness problems and molds at work and at home on development of asthma in adults. We recruited systematically all new cases of asthma during a 2.5-year study period (1997-2000) and randomly selected controls from a source population consisting of adults 21-63 years old living in the Pirkanmaa Hospital district, South Finland. The clinically diagnosed case series consisted of 521 adults with newly diagnosed asthma and the control series of 932 controls, after we excluded 76 (7.5%) controls with a history of asthma. In logistic regression analysis adjusting for confounders, the risk of asthma was related to the presence of visible mold and/or mold odor in the workplace (odds ratio, 1.54; 95% confidence interval, 1.01-2.32) but not to water damage or damp stains alone. We estimated the fraction of asthma attributable to workplace mold exposure to be 35.1% (95% confidence interval, 1.0-56.9%) among the exposed. Present results provide new evidence of the relation between workplace exposure to indoor molds and adult-onset asthma.
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影响因子：
5
作者：
MIETTINE.OS
通讯作者：
MIETTINE.OS
影响因子：
12.4
作者：
BRUNEKREEF, B
通讯作者：
BRUNEKREEF, B
影响因子：
5.4
作者：
HYNDMAN, SJ
通讯作者：
HYNDMAN, SJ
影响因子：
5
作者：
DALES, RE;ZWANENBURG, H;FRANKLIN, CA
通讯作者：
FRANKLIN, CA
DOI：
10.1164/ajrccm.157.2.9706033
发表时间：
1998-02-01
影响因子：
24.7
作者：
Nafstad, P;Oie, L;Jaakkola, JJK
通讯作者：
Jaakkola, JJK