Cell membrane modulation as adjuvant in cancer therapy.
Cell membrane modulation as adjuvant in cancer therapy.
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DOI：
10.1016/j.ctrv.2016.10.008
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发表时间：
2017-01
影响因子：
11.8
通讯作者：
ten Hagen, Timo L. M.
中科院分区：
文献类型：
--
作者：
Zalba, Sara;ten Hagen, Timo L. M.
癌症是一种复杂的疾病，涉及许多生物过程，这些过程可以并行存在，可以互补，或者在需要时参与，因此可以相互取代。癌细胞所具有的这种冗余可能性是治疗失败的根本原因。然而，肿瘤细胞和肿瘤作为一个整体的内在特征也提供了治疗的机会。在这里，我们讨论了肿瘤细胞的细胞膜的独特和具体的组成和安排，以及这些如何有助于治疗。有趣的是，关于细胞膜和相关结构的知识已经存在了几十年，而作为癌症治疗一部分的膜修饰和操纵的应用却滞后了。关于脂质和脂质代谢的科学工具的最新发展开辟了肿瘤细胞的新的和以前未知的方面，并表明与健康细胞相比，肿瘤细胞的脂质组成和膜功能可能存在差异。这一领域被称为脂质组学，它证明了细胞膜中脂质成分在几种疾病中的重要性。癌症中的重要变化，特别是与正常细胞相比，耐药癌细胞中的重要变化，为新的治疗策略打开了大门。此外，调节膜组分和/或性质的能力已经成为现实。在这里，癌症相关的脂质组学和策略的发展，以干扰癌细胞膜，以及如何影响癌症治疗进行了讨论。我们假设，脂质或膜靶向策略与现有护理相结合，以改善化疗，放疗和免疫治疗，将在未来几年带来急需的治疗变化。
Cancer is a complex disease involving numerous biological processes, which can exist in parallel, can be complementary, or are engaged when needed and as such can replace each other. This redundancy in possibilities cancer cells have, are fundamental to failure of therapy. However, intrinsic features of tumor cells and tumors as a whole provide also opportunities for therapy. Here we discuss the unique and specific makeup and arrangement of cell membranes of tumor cells and how these may help treatment. Interestingly, knowledge on cell membranes and associated structures is present already for decades, while application of membrane modification and manipulation as part of cancer therapy is lagging. Recent developments of scientific tools concerning lipids and lipid metabolism, opened new and previously unknown aspects of tumor cells and indicate possible differences in lipid composition and membrane function of tumor cells compared to healthy cells. This field, coined Lipidomics, demonstrates the importance of lipid components in cell membrane in several illnesses. Important alterations in cancer, and specially in resistant cancer cells compared to normal cells, opened the door to new therapeutic strategies. Moreover, the ability to modulate membrane components and/or properties has become a reality. Here, developments in cancer-related Lipidomics and strategies to interfere specifically with cancer cell membranes and how these affect cancer treatment are discussed. We hypothesize that combination of lipid or membrane targeted strategies with available care to improve chemotherapy, radiotherapy and immunotherapy will bring the much needed change in treatment in the years to come.
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