Role of mitochondrial lipids in guiding fission and fusion.
Role of mitochondrial lipids in guiding fission and fusion.
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DOI：
10.1007/s00109-014-1237-z
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发表时间：
2015-03
影响因子：
4.7
通讯作者：
Frohman, Michael A.
中科院分区：
文献类型：
--
作者：
Frohman, Michael A.
在信号机制、能量产生和肌肉细胞发育的背景下，线粒体功能与心脏生理和疾病之间已经建立了临床上重要的联系。目前已知，驱动线粒体融合和分裂的蛋白质和过程在细胞内钙稳态、细胞凋亡、血管平滑肌细胞增殖、肌原纤维组织和Notch驱动的细胞分化等方面具有紧急功能，所有这些都是心脏病的关键问题。此外，减少分裂可能提供对缺血性心脏病的保护，特别是在肥胖、糖尿病和心力衰竭的情况下。脂类在控制线粒体分裂和融合中的重要性日益受到重视。本文综述了大量和信号脂类心磷脂、磷脂酰乙醇胺、磷脂酸、二酰甘油和溶血磷脂酸及其合成或代谢酶在控制线粒体形态和功能中的作用。许多疾病都与部分酶的功能丧失等位基因有关，强调了脂质环境在这方面的重要性。
Clinically-important links have been established between mitochondrial function and cardiac physiology and disease in the context of signaling mechanisms, energy production, and muscle cell development. The proteins and processes that drive mitochondrial fusion and fission are now known to have emergent functions in intracellular calcium homeostasis, apoptosis, vascular smooth muscle cell proliferation, myofibril organization, and Notch-driven cell differentiation, all key issues in cardiac disease. Moreover, decreasing fission may confer protection against ischemic heart disease, particularly in the setting of obesity, diabetes, and heart failure. The importance of lipids in controlling mitochondrial fission and fusion is increasing becoming appreciated. Roles for the bulk and signaling lipids cardiolipin, phosphatidylethanolamine, phosphatidic acid, diacylglycerol, and lysophosphatidic acid and the enzymes that synthesize or metabolize them in the control of mitochondrial shape and function are reviewed here. A number of diseases have been linked to loss-of-function alleles for a subset of the enzymes, emphasizing the importance of the lipid environment in this context.
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影响因子：
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发表时间：
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