BOLD and its connection to dopamine release in human striatum: a cross-cohort comparison.
BOLD and its connection to dopamine release in human striatum: a cross-cohort comparison.
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DOI：
10.1098/rstb.2015.0352
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发表时间：
2016-10-05
期刊：
影响因子：
--
通讯作者：
Montague PR
中科院分区：
文献类型：
--
作者：
Lohrenz T;Kishida KT;Montague PR
Activity in midbrain dopamine neurons modulates the release of dopamine in terminal structures including the striatum, and controls reward-dependent valuation and choice. This fluctuating release of dopamine is thought to encode reward prediction error (RPE) signals and other value-related information crucial to decision-making, and such models have been used to track prediction error signals in the striatum as encoded by BOLD signals. However, until recently there have been no comparisons of BOLD responses and dopamine responses except for one clear correlation of these two signals in rodents. No such comparisons have been made in humans. Here, we report on the connection between the RPE-related BOLD signal recorded in one group of subjects carrying out an investment task, and the corresponding dopamine signal recorded directly using fast-scan cyclic voltammetry in a separate group of Parkinson's disease patients undergoing DBS surgery while performing the same task. The data display some correspondence between the signal types; however, there is not a one-to-one relationship. Further work is necessary to quantify the relationship between dopamine release, the BOLD signal and the computational models that have guided our understanding of both at the level of the striatum. This article is part of the themed issue ‘Interpreting BOLD: a dialogue between cognitive and cellular neuroscience’.
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影响因子：
4.7
作者：
Lammel S;Lim BK;Malenka RC
通讯作者：
Malenka RC
影响因子：
3
作者：
Ariansen JL;Heien ML;Hermans A;Phillips PE;Hernadi I;Bermudez MA;Schultz W;Wightman RM
通讯作者：
Wightman RM
影响因子：
10.9
作者：
D'Haese, Pierre-Francois;Pallavaram, Srivatsan;Li, Rui;Remple, Michael S.;Kao, Chris;Neimat, Joseph S.;Konrad, Peter E.;Dawant, Benoit M.
通讯作者：
Dawant, Benoit M.
DOI：
10.1073/pnas.1513619112
发表时间：
2016-01-05
影响因子：
11.1
作者：
Kishida, Kenneth T.;Saez, Ignacio;Montague, P. Read
通讯作者：
Montague, P. Read
影响因子：
5.3
作者：
Hart, Andrew S.;Rutledge, Robb B.;Phillips, Paul E. M.
通讯作者：
Phillips, Paul E. M.