Haplotype structure, adaptive history and associations with exploratory behaviour of the DRD4 gene region in four great tit (Parus major) populations
Haplotype structure, adaptive history and associations with exploratory behaviour of the DRD4 gene region in four great tit (Parus major) populations
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四个大山雀种群中 DRD4 基因区域的单倍型结构、适应历史及其与探索行为的关联
DOI：
10.1111/mec.12282
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发表时间：
2013
影响因子：
4.9
通讯作者：
Kempenaers B
中科院分区：
文献类型：
--
作者：
Mueller JC;Korsten P;Hermannstaedter C;Feulner T;Dingemanse NJ;Matthysen E;van Oers K;van Overveld T;Patrick SC;Quinn JL;Riemenschneider M;Tinbergen JM;Kempenaers B
行为特征基因的遗传结构和选择历史的评估是我们理解这些特征如何进化的基础。多巴胺受体D4（DRD4）基因是解释新奇行为遗传变异的主要候选者，求新行为是动物中常见的人格特征。在此之前，我们表明，在该基因的外显子3的单核苷酸多态性与探索行为在至少一个西欧大山雀（山雀）人口。这些异质关联的结果解释了潜在的变量之间的连锁不平衡（LD）模式，该标记和因果变异或其他遗传或环境差异的人口。不同的适应历史进一步假设，这些人口差异。在这里，我们对四个群体的595个个体的包括侧翼区的完整DRD4基因的98个多态性进行了基因分型。我们发现LD结构，特别是在原始外显子3 SNP周围，在四个人群中是保守的，并且不能解释异质性关联结果。在具有不同等位基因效应模型的四个测试人群中的两个中，在外显子2、3和4周围的一个以上单倍型块中检测到与探索行为的研究范围内的显著关联。这表明多个DRD4多态性和探索行为之间的关联在人群中的遗传异质性。关联信号位于或接近具有正选择特征的区域。因此，我们假设探索性行为和其他多巴胺相关行为的变化通过潜在遗传变异频率的偶尔适应性变化而局部演变。
The assessment of genetic architecture and selection history in genes for behavioural traits is fundamental to our understanding of how these traits evolve. The dopamine receptor D4 (DRD4) gene is a prime candidate for explaining genetic variation in novelty seeking behaviour, a commonly assayed personality trait in animals. Previously, we showed that a single nucleotide polymorphism in exon 3 of this gene is associated with exploratory behaviour in at least one of four Western European great tit (Parus major) populations. These heterogeneous association results were explained by potential variable linkage disequilibrium (LD) patterns between this marker and the causal variant or by other genetic or environmental differences among the populations. Different adaptive histories are further hypothesized to have contributed to these population differences. Here, we genotyped 98 polymorphisms of the completeDRD4gene including the flanking regions for 595 individuals of the four populations. We show that the LD structure, specifically around the original exon 3 SNP is conserved across the four populations and does not explain the heterogeneous association results. Study‐wide significant associations with exploratory behaviour were detected in more than one haplotype block around exon 2, 3 and 4 in two of the four tested populations with different allele effect models. This indicates genetic heterogeneity in the association between multipleDRD4polymorphisms and exploratory behaviour across populations. The association signals were in or close to regions with signatures of positive selection. We therefore hypothesize that variation in exploratory and other dopamine‐related behaviour evolves locally by occasional adaptive shifts in the frequency of underlying genetic variants.
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影响因子：
9.8
作者：
Wang, E;Ding, YC;Moyzis, RK
通讯作者：
Moyzis, RK
美洲印第安人的多巴胺受体 D4 等位基因分布：反映过去的行为差异？
影响因子：
2.8
作者：
L. Tovo;S. Callegari;M. Petzl;L. Tsuneto;F. Salzano;M. Hutz
通讯作者：
M. Hutz
DOI：
--
发表时间：
2012
期刊：
Proceedings of the Royal Society B: Biological Sciences
影响因子：
--
作者：
M. Nicolaus;J. Tinbergen;K. Bouwman;S. Michler;R. Ubels;C. Both;B. Kempenaers;N. Dingemanse
通讯作者：
N. Dingemanse
DOI：
10.1111/j.2517-6161.1977.tb01600.x
发表时间：
1977-01-01
期刊：
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-METHODOLOGICAL
影响因子：
--
作者：
DEMPSTER, AP;LAIRD, NM;RUBIN, DB
通讯作者：
RUBIN, DB
DOI：
10.1098/rspb.2002.2168
发表时间：
2003-01-07
影响因子：
4.7
作者：
Drent, PJ;van Oers, K;van Noordwijk, AJ
通讯作者：
van Noordwijk, AJ