Initial in vivo rodent sodium and proton MR imaging at 21.1 T.
Initial in vivo rodent sodium and proton MR imaging at 21.1 T.
复制标题
DOI：
10.1016/j.mri.2009.10.002
复制
发表时间：
2010-04
影响因子：
2.5
通讯作者：
Grant, Samuel C.
中科院分区：
文献类型：
--
作者：
Schepkin, Victor D.;Brey, William W.;Gor'kov, Peter L.;Grant, Samuel C.
在美国佛罗里达州塔拉哈西国家强磁场实验室建造和运行的大口径(105 Mm)高分辨率21.1T磁体上，首次获得了啮齿类动物的在体钠和质子磁共振图像和定位光谱。用自制的射频探头以237/900 MHz频率分别采集正常小鼠(C57BL/6J)和Fisher大鼠(~250g)的头部图像。利用3D反投影脉冲序列，获得了小鼠和大鼠头部的钠-L分辨率约为0.125μ。与9.4T下获得的相应MR图像相比，钠的信噪比提高了~3倍，质子的信噪比提高了~2倍。在90min内获得了3D闪光质子小鼠图像(50×50×50μm~3)，在120min内获得了相应的大鼠图像(100×100×100μm~3)。在体大啮齿动物磁共振成像和21.1T极高场的局域光谱分析都是可行的，并显示出更高的分辨率和灵敏度，对脑结构和功能分析具有重要价值。
The first in vivo sodium and proton MR images and localized spectra of rodents were attained using the wide bore (105 mm) high resolution 21.1 T magnet, built and operated at the National High Magnetic Field Laboratory (Tallahassee, FL). Head images of normal mice (C57BL/6J) and Fisher rats (~ 250 g) were acquired with custom designed RF probes at frequencies of 237/900 MHz for sodium and proton, respectively. Sodium MRI resolutions of ~0.125 μL for mouse and rat heads were achieved by using a 3D back-projection pulse sequence. A gain in SNR of ~ 3 for sodium and of ~ 2 times for proton were found relative to corresponding MR images acquired at 9.4 T. 3D FLASH proton mouse images (50×50×50 μm3) were acquired in 90 min and corresponding rat images (100×100×100 μm3) within a total time of 120 min. Both in vivo large rodent MR imaging and localized spectroscopy at the extremely high field of 21.1 T are feasible and demonstrate improved resolution and sensitivity valuable for structural and functional brain analysis.
登录
查看更多内容
影响因子：
2.2
作者：
Mlynarik, Vladimir;Cudalbu, Cristina;Gruetter, Rolf
通讯作者：
Gruetter, Rolf
影响因子：
2.5
作者：
Dobre, Mircea C.;Ugurbil, Kamil;Marjanska, Malgorzata
通讯作者：
Marjanska, Malgorzata
影响因子：
3.3
作者：
Maï, W;Badea, CT;Johnson, GA
通讯作者：
Johnson, GA
影响因子：
2.9
作者：
Gareis, Daniel;Wichmann, Tobias;Jakob, Peter M.
通讯作者：
Jakob, Peter M.
影响因子：
2.2
作者：
Alecci, M.;Romanzetti, S.;Shah, N. J.
通讯作者：
Shah, N. J.