The effect of administration of fenbendazole on the microbial hindgut population of the horse.
The effect of administration of fenbendazole on the microbial hindgut population of the horse.
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DOI:
10.1294/jes.29.47
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发表时间:
2018
影响因子:
--
通讯作者:
McEwan NR
中科院分区:
文献类型:
--
作者:
Crotch-Harvey L;Thomas LA;Worgan HJ;Douglas JL;Gilby DE;McEwan NR
Anthelmintics are used as anti-worming agents. Although known to affect their target organisms, nothing has been published regarding their effect on other digestive tract organisms or on metabolites produced by them. The current work investigated effects of fenbendazole, a benzimidazole anthelmintic, on bacteria and ciliates in the equine digestive tract and on and their major metabolites. Animals receiving anthelmintic treatment had high faecal egg counts relative to controls. Analysis was performed over two weeks, with temporal differences detected in bacterial populations but with no other significant differences detected. This suggests fenbendazole has no detectable effect on organisms other than its targets. Moreover it does not appear to make a contribution to changing the resulting metabolome.
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