Comparison of carcinoembryonic antigen prognostic value in serum and tumour tissue of patients with colorectal cancer.
Comparison of carcinoembryonic antigen prognostic value in serum and tumour tissue of patients with colorectal cancer.
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DOI：
10.1111/j.1463-1318.2008.01591.x
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Gu J
中科院分区：
文献类型：
--
作者：
Li M;Li JY;Zhao AL;He JS;Zhou LX;Li YA;Gu J
大肠癌（CRC）患者血清和肿瘤组织中的癌胚抗原（CEA）是诊断和评估预后或治疗后复发的最常用的肿瘤标志物，但其作用仍存在争议。本研究的目的是比较血清和肿瘤组织中CEA在结直肠癌中的预后价值。回顾性分析了173例I ~ III期结直肠癌患者，以根治性手术后复发或转移为终点。在血清和肿瘤组织中评估CEA。37.0%（64/173）的患者血清CEA（S-CEA）升高，39.3%（68/173）的患者肿瘤组织CEA（T-CEA）升高。低S-CEA组和高T-CEA组的临床病理特征无显著差异。高S-CEA组预后较低S-CEA组差，但差异无统计学意义。在单因素分析中，高T-CEA组的预后显著差于低T-CEA组（P=0.028）。多因素分析表明T-CEA是结直肠癌的独立预后因素。由于影响S-CEA浓度的因素较多，故S-CEA与T-CEA之间无直接相关性。我们的研究表明，高T-CEA浓度可能是结直肠癌患者手术后预后不良的一个有用和独立的预测因子。它可能比术前高血清CEA水平更强。
Carcinoembryonic antigen (CEA) in the serum and the tumour tissue of colorectal cancer (CRC) patients is the most commonly used tumour marker for the diagnosis and evaluation of prognosis or recurrence after treatment, but the role remains controversial. The objective of this study was to compare the prognostic value of CEA both in serum and tumour tissue in CRC. A total of 173 patients with CRC in stages I–III were retrospectively assessed with the endpoint of recurrence or metastasis after curative operation. CEA was assessed both in serum and tumour tissue. 37.0% (64/173) patients had a high level of CEA in serum (S-CEA) while 39.3% (68/173) had high CEA in tumour tissue (T-CEA). There were no significant differences in clinico-pathological features between the low and high S-CEA or T-CEA groups. The high S-CEA group had a worse prognosis than the low S-CEA group but the difference was not significant. The high T-CEA group had a significantly poorer prognosis than the low T-CEA group (P=0.028) in the univariate analysis. The multivariate analysis demonstrated that the T-CEA was an independent prognosis factor in CRC. Because many factors would affect the concentration of S-CEA, there was no correlation between S-CEA and T-CEA directly. Our study suggests that a high T-CEA concentration may be a useful and independent predictor for poor outcome after surgery in CRC patients. It may be stronger than a high preoperative serum CEA level.
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DOI：
10.1084/jem.122.3.467
发表时间：
1965-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gold P;Freedman SO
通讯作者：
Freedman SO
影响因子：
3.4
作者：
Leeman, MF;McKay, JA;Murray, GI
通讯作者：
Murray, GI
影响因子：
3.9
作者：
BLAKE, KE;DALBOW, MH;HEADINGS, JJ
通讯作者：
HEADINGS, JJ
影响因子：
3.2
作者：
Kim, JC;Roh, SA;Kim, JS
通讯作者：
Kim, JS
影响因子：
5.2
作者：
Harrison, LE;Guillem, JG;Cohen, AM
通讯作者：
Cohen, AM