Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity.
Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity.
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DOI：
10.3390/v13061106
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发表时间：
2021-06-09
期刊：
影响因子：
--
通讯作者：
Permar SR
中科院分区：
文献类型：
--
作者：
Wang HY;Valencia SM;Pfeifer SP;Jensen JD;Kowalik TF;Permar SR
人巨细胞病毒（HCMV）是地球仪上最流行的病毒之一，是免疫功能低下个体发病和死亡的常见原因。最近的临床观察表明，混合菌株感染很常见，可能导致更严重的疾病进展。这一临床观察结果说明了HCMV基因组的复杂性，并强调了从人群水平观察基因型进化的重要性。在这里，我们经常采样多态性的HCMV的糖蛋白，比较可变区，并总结其相应的地理分布观察到的日期。还讨论了相关的毒株特异性免疫，包括中和活性和抗原特异性细胞免疫。鉴于这些糖蛋白是疫苗设计和抗病毒治疗的常见靶标，这种观察到的遗传变异代表了未来对抗HCMV感染的重要资源。
Human cytomegalovirus (HCMV), one of the most prevalent viruses across the globe, is a common cause of morbidity and mortality for immunocompromised individuals. Recent clinical observations have demonstrated that mixed strain infections are common and may lead to more severe disease progression. This clinical observation illustrates the complexity of the HCMV genome and emphasizes the importance of taking a population-level view of genotypic evolution. Here we review frequently sampled polymorphisms in the glycoproteins of HCMV, comparing the variable regions, and summarizing their corresponding geographic distributions observed to date. The related strain-specific immunity, including neutralization activity and antigen-specific cellular immunity, is also discussed. Given that these glycoproteins are common targets for vaccine design and anti-viral therapies, this observed genetic variation represents an important resource for future efforts to combat HCMV infections.
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影响因子：
5.5
作者：
Bernstein DI;Munoz FM;Callahan ST;Rupp R;Wootton SH;Edwards KM;Turley CB;Stanberry LR;Patel SM;Mcneal MM;Pichon S;Amegashie C;Bellamy AR
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Bellamy AR
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作者：
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作者：
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通讯作者：
Wickes, Brian L.
DOI：
10.1590/s0036-46652004000200006
发表时间：
2004-04-01
期刊：
Revista do Instituto de Medicina Tropical de São Paulo
影响因子：
--
作者：
Ahumada-Ruiz, Sara;Taylor-Castillo, Lizeth;Herrero-Uribe, Libia
通讯作者：
Herrero-Uribe, Libia