CSF metabolic and proteomic profiles in patients prodromal for psychosis.
CSF metabolic and proteomic profiles in patients prodromal for psychosis.
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DOI：
10.1371/journal.pone.0000756
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发表时间：
2007-08-22
期刊：
影响因子：
3.7
通讯作者：
Bahn S
中科院分区：
文献类型：
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作者：
Huang JT;Leweke FM;Tsang TM;Koethe D;Kranaster L;Gerth CW;Gross S;Schreiber D;Ruhrmann S;Schultze-Lutter F;Klosterkötter J;Holmes E;Bahn S
精神病的初始前驱状态（IPS）定义为在明显精神病发作之前的早期疾病阶段，其特征在于亚阈值或更多非特异性精神症状。关于这一时期的生物化学变化知之甚少。我们分别使用质子核磁共振（1H-NMR）光谱和表面增强激光解吸电离（SELDI）质谱研究了首次发作的药物初治偏执型精神分裂症患者（n= 54）和出现初始前驱症状的个体（n = 24）以及健康志愿者（n =70）的脑脊液（CSF）的代谢/蛋白质组学谱。 偏最小二乘判别分析（PLS-DA）显示，36%/29%的IPS患者表现出首发、药物初治精神分裂症的蛋白质组/代谢特征，即，葡萄糖和乳酸水平的变化以及VEGF衍生肽（VGF 23 -62）和甲状腺素运载蛋白蛋白浓度的变化。然而，只有29%（n = 7）的调查IPS患者（迄今已随访长达三年）迄今已收到精神分裂症的诊断。 IPS组中存在的生化改变与发展为精神分裂症的风险无关。我们的研究结果表明，精神分裂症相关的生化疾病的过程可以追溯到前驱患者的CSF。然而，在IPS患者中确定的生化紊乱，至少在单个时间点测量时，可能不足以预测临床结果。
The initial prodromal state of psychosis (IPS) is defined as an early disease stage prior to the onset of overt psychosis characterized by sub-threshold or more unspecific psychiatric symptoms. Little is known regarding the biochemical changes during this period. We investigated the metabolic/proteomic profiles of cerebrospinal fluid (CSF) of first-onset drug naïve paranoid schizophrenia patients (n = 54) and individuals presenting with initial prodromal symptoms (n = 24), alongside healthy volunteers (n = 70) using proton nuclear magnetic resonance (1H-NMR) spectroscopy and surface enhanced laser desorption ionization (SELDI) mass spectrometry, respectively. Partial least square discriminant analysis (PLS-DA) showed that 36%/29% of IPS patients displayed proteomic/metabolic profiles characteristic of first-onset, drug naïve schizophrenia, i.e., changes in levels of glucose and lactate as well as changes in a VGF-derived peptide (VGF23-62) and transthyretin protein concentrations. However, only 29% (n = 7) of the investigated IPS patients (who to date have been followed up for up to three years) have so far received a diagnosis of schizophrenia. The presence of biochemical alterations in the IPS group did not correlate with the risk to develop schizophrenia. Our results imply that schizophrenia-related biochemical disease processes can be traced in CSF of prodromal patients. However, the biochemical disturbances identified in IPS patients, at least when measured at a single time point, may not be sufficient to predict clinical outcome.
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影响因子：
--
作者：
Klosterkötter, J;Hellmich, M;Schultze-Lutter, F
通讯作者：
Schultze-Lutter, F
影响因子：
16.2
作者：
Hahm, S;Mizuno, TM;Salton, SRJ
通讯作者：
Salton, SRJ
影响因子：
--
作者：
HAWKINS, RA;MANS, AM;DAVIS, DW
通讯作者：
DAVIS, DW
影响因子：
17.7
作者：
McGlashan, TH;Zipursky, RB;Breier, A
通讯作者：
Breier, A
影响因子：
3.5
作者：
Miller, TJ;McGlashan, TH;Davidson, L
通讯作者：
Davidson, L