Development of the hippocampal CA2 region and the emergence of social recognition.
Development of the hippocampal CA2 region and the emergence of social recognition.
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DOI：
10.1002/dneu.22919
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发表时间：
2023-07
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
作者：
早年形成的社会记忆，就像家人和不相关的同龄人的记忆一样，众所周知有助于一生中健康的社会互动，尽管发育中的大脑如何支持社会记忆仍然相对未知。海马区的CA2亚区与社会记忆功能有关，但大多数关于这一主题的文献仅限于对成年啮齿动物的研究。在这里，我们回顾了目前关于哺乳动物海马区CA2区胚胎和出生后发育的文献，重点介绍了其不寻常的分子和细胞特征的出现，包括其显著高表达的可塑性抑制分子。我们还考虑了CA2与其他脑区的连接，包括海马区，如齿状回、CA3和CA1区，以及海马区外，如下丘脑、腹侧被盖区、基底前脑、中缝核团和内嗅皮层。我们回顾了CA2分子、细胞和电路水平特征的发展里程碑，这些特征可能有助于在早期生命中出现对亲缘和无关同种的社会识别能力。最后，我们考虑与人类神经发育障碍相关的遗传小鼠模型，以调查CA2的非典型形成是否可能有助于社会记忆功能障碍的证据。
Social memories formed in early life, like those for family and unrelated peers, are known to contribute to healthy social interactions throughout life, although how the developing brain supports social memory remains relatively unexplored. The CA2 subregion of the hippocampus is involved in social memory function, but most literature on this subject is restricted to studies of adult rodents. Here, we review the current literature on the embryonic and postnatal development of hippocampal subregion CA2 in mammals, with a focus on the emergence of its unusual molecular and cellular characteristics, including its notably high expression of plasticity-suppressing molecules. We also consider the connectivity of the CA2 with other brain areas, including intrahippocampal regions, such as the dentate gyrus, CA3, and CA1 regions, and extrahippocampal regions, such as the hypothalamus, ventral tegmental area, basal forebrain, raphe nuclei, and the entorhinal cortex. We review developmental milestones of CA2 molecular, cellular, and circuit-level features that may contribute to emerging social recognition abilities for kin and unrelated conspecifics in early life. Lastly, we consider genetic mouse models related to neurodevelopmental disorders in humans in order to survey evidence about whether atypical formation of the CA2 may contribute to social memory dysfunction.
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影响因子：
3.5
作者：
Villard, Justine;Bennett, Jeffrey L.;Bliss-Moreau, Eliza;Capitanio, John P.;Fox, Nathan A.;Amaral, David G.;Lavenex, Pierre
通讯作者：
Lavenex, Pierre
影响因子：
3
作者：
Beery AK;Christensen JD;Lee NS;Blandino KL
通讯作者：
Blandino KL
影响因子：
2.9
作者：
Botcher NA;Falck JE;Thomson AM;Mercer A
通讯作者：
Mercer A
影响因子：
3.6
作者：
Campbell, L. E.;McCabe, K. L.;Schall, U.
通讯作者：
Schall, U.
影响因子：
3.7
作者：
Caruana, Douglas A.;Dudek, Serena M.
通讯作者：
Dudek, Serena M.