Characteristics and outcomes of 627 044 COVID-19 patients living with and without obesity in the United States, Spain, and the United Kingdom.
Characteristics and outcomes of 627 044 COVID-19 patients living with and without obesity in the United States, Spain, and the United Kingdom.
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DOI：
10.1038/s41366-021-00893-4
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Duarte-Salles T
中科院分区：
文献类型：
--
作者：
Recalde M;Roel E;Pistillo A;Sena AG;Prats-Uribe A;Ahmed WU;Alghoul H;Alshammari TM;Alser O;Areia C;Burn E;Casajust P;Dawoud D;DuVall SL;Falconer T;Fernández-Bertolín S;Golozar A;Gong M;Lai LYH;Lane JCE;Lynch KE;Matheny ME;Mehta PP;Morales DR;Natarjan K;Nyberg F;Posada JD;Reich CG;Rijnbeek PR;Schilling LM;Shah K;Shah NH;Subbian V;Zhang L;Zhu H;Ryan P;Prieto-Alhambra D;Kostka K;Duarte-Salles T
尚未对患有COVID-19的肥胖患者进行详细描述。我们的目的是描述和比较COVID-19肥胖患者（PLWO）与非肥胖患者的人口统计学、医疗状况和结局。我们根据西班牙、英国和美国2020年1月至6月的门诊/住院护理和索赔数据进行了一项队列研究。我们使用了六个数据库标准化的OMOP通用数据模型。我们定义了两个非相互排斥的队列，这些队列由确诊和/或住院的COVID-19患者组成;患者从索引日期开始随访至30天或死亡。我们报告了肥胖状态的人口统计学、既往医疗状况和30天结局（住院、事件和死亡）的频率。我们纳入了627 044例（西班牙：122 058例，英国：2336例，美国：502 650例）确诊和160 013例（西班牙：18 197例，美国：141 816例）住院的COVID-19患者。住院患者的肥胖患病率（39.9%，95%CI：39.8 - 40.0）高于确诊为COVID-19的患者（33.1%; 95%CI：33.0 - 33.2）。在两个队列中，PLWO更常见于女性。住院PLWO比非肥胖患者年轻。总体而言，与无肥胖的COVID-19患者相比，COVID-19 PLWO更有可能有既往病史，在住院期间出现心血管和呼吸系统事件，或需要强化服务。我们发现，PLWO与非肥胖患者在广泛的医疗条件方面存在差异，并表现出更严重的COVID-19形式，住院率更高，需要强化服务。这些发现有助于指导COVID-19感染和并发症的预防策略，并为因果推理研究提供假设。
A detailed characterization of patients with COVID-19 living with obesity has not yet been undertaken. We aimed to describe and compare the demographics, medical conditions, and outcomes of COVID-19 patients living with obesity (PLWO) to those of patients living without obesity. We conducted a cohort study based on outpatient/inpatient care and claims data from January to June 2020 from Spain, the UK, and the US. We used six databases standardized to the OMOP common data model. We defined two non-mutually exclusive cohorts of patients diagnosed and/or hospitalized with COVID-19; patients were followed from index date to 30 days or death. We report the frequency of demographics, prior medical conditions, and 30-days outcomes (hospitalization, events, and death) by obesity status. We included 627 044 (Spain: 122 058, UK: 2336, and US: 502 650) diagnosed and 160 013 (Spain: 18 197, US: 141 816) hospitalized patients with COVID-19. The prevalence of obesity was higher among patients hospitalized (39.9%, 95%CI: 39.8−40.0) than among those diagnosed with COVID-19 (33.1%; 95%CI: 33.0−33.2). In both cohorts, PLWO were more often female. Hospitalized PLWO were younger than patients without obesity. Overall, COVID-19 PLWO were more likely to have prior medical conditions, present with cardiovascular and respiratory events during hospitalization, or require intensive services compared to COVID-19 patients without obesity. We show that PLWO differ from patients without obesity in a wide range of medical conditions and present with more severe forms of COVID-19, with higher hospitalization rates and intensive services requirements. These findings can help guiding preventive strategies of COVID-19 infection and complications and generating hypotheses for causal inference studies.
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DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
影响因子：
8.9
作者：
Popkin, Barry M.;Du, Shufa;Shekar, Meera
通讯作者：
Shekar, Meera
影响因子：
11.8
作者：
Louie, Janice K.;Acosta, Meileen;Matyas, Bela T.
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Matyas, Bela T.
影响因子：
9.8
作者：
Du, Yanbin;Lv, Yuan;Hong, Xiuqin
通讯作者：
Hong, Xiuqin
影响因子：
16.6
作者：
Burn E;You SC;Sena AG;Kostka K;Abedtash H;Abrahão MTF;Alberga A;Alghoul H;Alser O;Alshammari TM;Aragon M;Areia C;Banda JM;Cho J;Culhane AC;Davydov A;DeFalco FJ;Duarte-Salles T;DuVall S;Falconer T;Fernandez-Bertolin S;Gao W;Golozar A;Hardin J;Hripcsak G;Huser V;Jeon H;Jing Y;Jung CY;Kaas-Hansen BS;Kaduk D;Kent S;Kim Y;Kolovos S;Lane JCE;Lee H;Lynch KE;Makadia R;Matheny ME;Mehta PP;Morales DR;Natarajan K;Nyberg F;Ostropolets A;Park RW;Park J;Posada JD;Prats-Uribe A;Rao G;Reich C;Rho Y;Rijnbeek P;Schilling LM;Schuemie M;Shah NH;Shoaibi A;Song S;Spotnitz M;Suchard MA;Swerdel JN;Vizcaya D;Volpe S;Wen H;Williams AE;Yimer BB;Zhang L;Zhuk O;Prieto-Alhambra D;Ryan P
通讯作者：
Ryan P