Qualitative content analysis of public responses to an FDA inquiry on the impact of scheduling changes to kratom.
Qualitative content analysis of public responses to an FDA inquiry on the impact of scheduling changes to kratom.
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DOI：
10.1016/j.drugpo.2022.103817
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发表时间：
2022-10
影响因子：
4.4
通讯作者：
Brents, Lisa K.
中科院分区：
文献类型：
--
作者：
Tobacyk, Julia;Parks, Brian J.;Lovelady, Nakita;Brents, Lisa K.
关键词：
KrATOM在美国的法律地位很复杂，各州的情况各不相同。美国食品和药物管理局(FDA)和美国禁毒署一再对KrATOM进行监管审查。然而，还没有对公众对Krtom的看法进行系统的审查。本研究分析了公众对FDA征求有关KrATOM信息的无限期反应，目的是全面评估KrATOM的使用动机。为了指导有关KrATOM监管的决定，FDA征求了有关KrATOM滥用潜力、医疗有用性和2021年7月至8月时间表变化的影响的意见，并将其发布在联邦登记册网站上。我们通过定性的内容分析，使用归纳法分析了在评论征集的前6周发布的评论(6,353条)。受访者报告了106个与健康有关的使用KrATOM的独立原因，其中大多数归类为心理健康、疼痛管理、物质使用障碍或其他目的，包括增加注意力、治疗失眠和减少疲劳。神经系统疾病和消化系统疾病也有报道。相对较少的(<；2%)受访者报告娱乐用途、滥用可能性或KrATOM的不良影响。虽然KrATOM没有被批准为任何适应症的安全有效的治疗方法，但个人将KrATOM用于广泛的健康相关目的。这项研究的局限性包括对使用KrATOM有积极体验的受访者可能存在偏见，缺乏人口统计学数据，以及对受访者的说法缺乏独立核实。无论如何，这项研究反映了人们对KrATOM治疗用途的看法，并提供了对美国监管KrATOM的潜在个人层面后果的洞察。重要的是，研究公众对KrATOM使用的看法，这有助于监管目的，并提供有关个人使用和评估KrATOM的临床重要信息。
The legal status of kratom in the United States is complex and varies by state. The U.S. Food and Drug Administration (FDA) and the U.S. Drug Enforcement Administration have repeatedly subjected kratom to regulatory review. However, there hasn’t been a systematic review of the public’s perception of kratom. The present study analyzed open-ended responses from the public to an FDA solicitation for information regarding kratom with the goal of providing a comprehensive assessment of motives for kratom use. To guide decisions regarding kratom regulation, the FDA solicited comments regarding kratom abuse potential, medical usefulness, and impact of scheduling changes from July through August 2021 and posted them to the Federal Register website. We analyzed comments posted during the first 6 weeks of comment solicitation (6,353) using an inductive approach via qualitative content analysis. Respondents reported 106 independent health-related reasons for kratom use, with most categorized as mental health, pain management, substance use disorder, or miscellaneous purposes that included increasing focus, treating insomnia, and decreasing fatigue. Neurological diseases and digestive disorders were also reported. Relatively few (< 2%) responses reported recreational use, abuse potential, or adverse effects of kratom. Although kratom is not approved as a safe and effective therapy for any indication, individuals use kratom for a broad spectrum of health-related purposes. Limitations of this study include potential bias for respondents with perceived positive experiences using kratom, lack of demographics data, and lack of independent verification of claims made by respondents. Regardless, this study reflects perceptions regarding the therapeutic uses of kratom and provides insight into potential individual-level consequences of regulating kratom in the U.S. It is important to study the public’s perception of kratom use, which can aid regulatory purposes and provide clinically important information on individuals’ use and valuation of kratom.
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影响因子：
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作者：
Cinosi E;Martinotti G;Simonato P;Singh D;Demetrovics Z;Roman-Urrestarazu A;Bersani FS;Vicknasingam B;Piazzon G;Li JH;Yu WJ;Kapitány-Fövény M;Farkas J;Di Giannantonio M;Corazza O
通讯作者：
Corazza O
影响因子：
4.2
作者：
Foss, Jeffery D.;Nayak, Sunil U.;Rawls, Scott M.
通讯作者：
Rawls, Scott M.
影响因子：
4.1
作者：
Eggleston, William;Stoppacher, Robert;Nelson, Lewis S.
通讯作者：
Nelson, Lewis S.
影响因子：
4.2
作者：
Bunting AM;Frank D;Arshonsky J;Bragg MA;Friedman SR;Krawczyk N
通讯作者：
Krawczyk N
DOI：
10.1016/j.drugpo.2021.103140
发表时间：
2021-06
期刊：
The International journal on drug policy
影响因子：
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作者：
Krawczyk N;Bunting AM;Frank D;Arshonsky J;Gu Y;Friedman SR;Bragg MA
通讯作者：
Bragg MA