Precision medicine in type 1 diabetes.
Precision medicine in type 1 diabetes.
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DOI:
10.1007/s00125-022-05778-3
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发表时间:
2022-11
期刊:
影响因子:
8.2
通讯作者:
Oram, Richard A.
中科院分区:
文献类型:
--
作者:
Carr, Alice L. J.;Evans-Molina, Carmella;Oram, Richard A.
关键词:
First envisioned by early diabetes clinicians, a person-centred approach to care was an aspirational goal that aimed to match insulin therapy to each individual’s unique requirements. In the 100 years since the discovery of insulin, this goal has evolved to include personalised approaches to type 1 diabetes diagnosis, treatment, prevention and prediction. These advances have been facilitated by the recognition of type 1 diabetes as an autoimmune disease and by advances in our understanding of diabetes pathophysiology, genetics and natural history, which have occurred in parallel with advancements in insulin delivery, glucose monitoring and tools for self-management. In this review, we discuss how these personalised approaches have improved diabetes care and how improved understanding of pathogenesis and human biology might inform precision medicine in the future. The online version contains a slideset of the figures for download available at 10.1007/s00125-022-05778-3.
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