Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity.
Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity.
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DOI：
10.1016/j.chom.2013.04.005
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发表时间：
2013-05-15
影响因子：
30.3
通讯作者：
Inohara N
中科院分区：
文献类型：
--
作者：
Jiao Y;Darzi Y;Tawaratsumida K;Marchesan JT;Hasegawa M;Moon H;Chen GY;Núñez G;Giannobile WV;Raes J;Inohara N
牙周炎是一种常见的疾病，以牙槽骨吸收为特征，由共生细菌介导，通过未知的机制触发宿主免疫反应和骨破坏。我们报道，Nod1是细菌肽聚糖相关分子的固有细胞内宿主受体，在小鼠模型中对共生体诱导的牙周炎至关重要。缺乏Nod1的小鼠表现出骨吸收减少，中性粒细胞募集到牙龈组织和破骨细胞募集到牙槽骨组织，这介导了组织和骨的破坏。进一步的分析表明，刺激Nod1的共生菌NI1060在牙龈部位的积累足以诱导中性粒细胞招募和骨吸收。基因组测序显示，NI1060是一种小鼠特有的细菌，与人类侵袭性牙周炎的发展相关。这些发现为促进牙周炎的共生宿主相互作用提供了洞察力，并确定了预防这种常见口腔疾病的潜在靶点。
Periodontitis is a common disease that is characterized by resorption of the alveolar bone and mediated by commensal bacteria that trigger host immune responses and bone destruction through unidentified mechanisms. We report that Nod1, an innate intracellular host receptor for bacterial peptidoglycan-related molecules, is critical for commensal-induced periodontitis in a mouse model. Mice lacking Nod1 exhibit reduced bone resorption as well as impaired recruitment of neutrophils to gingival tissues and osteoclasts to the alveolar bone, which mediate tissue and bone destruction. Further analysis showed that accumulation of a Nod1-stimulating commensal bacterium, NI1060, at gingival sites was sufficient to induce neutrophil recruitment and bone resorption. Genomic sequencing revealed that NI1060 is a mouse-specific bacterium that is related to bacteria associated with the development of aggressive periodontitis in humans. These findings provide insight into commensal-host interactions contributing to periodontitis and identify a potential target for preventing this common oral disease.
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影响因子：
30.5
作者：
通讯作者：
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聚糖代谢如何塑造人类肠道微生物群。
DOI：
10.1038/nrmicro2746
发表时间：
2012-04-11
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
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DOI：
10.4049/jimmunol.1200821
发表时间：
2012-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hasegawa M;Kamada N;Jiao Y;Liu MZ;Núñez G;Inohara N
通讯作者：
Inohara N
DOI：
10.1159/000329675
发表时间：
2012
期刊：
Frontiers of oral biology
影响因子：
--
作者：
Graves DT;Kang J;Andriankaja O;Wada K;Rossa C Jr
通讯作者：
Rossa C Jr
影响因子：
3.1
作者：
Hasegawa, Mizuho;Osaka, Toshifumi;Inohara, Naohiro
通讯作者：
Inohara, Naohiro