More Than Meets the Eye Regarding Cancer Metabolism.
More Than Meets the Eye Regarding Cancer Metabolism.
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DOI：
10.3390/ijms22179507
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发表时间：
2021-09-01
影响因子：
5.6
通讯作者：
Łabieniec-Watała M
中科院分区：
文献类型：
--
作者：
Kubicka A;Matczak K;Łabieniec-Watała M
尽管我们对癌症的性质、形成原因和新的治疗方法的认识不断提高，但我们的知识仍然是不完整的。一个关键问题是正常细胞和癌细胞之间的代谢差异。区分癌细胞与正常细胞的特征是这些细胞的增殖增加和异常分化和成熟，这是由于新兴肿瘤中的调节变化。正常细胞在分裂过程中使用氧化磷酸化（OXPHOS）作为主要的能量来源。在OXPHOS过程中，一个葡萄糖分子产生36个ATP分子，而糖酵解只提供两个ATP分子。虽然有氧葡萄糖代谢更有效，但基于密集糖酵解的代谢提供了合成核酸、蛋白质和脂质所必需的中间代谢物，由于癌症中强烈的细胞分裂，这些物质的需求量一直很高。这就是为什么癌细胞不“放弃”糖酵解的主要原因，尽管对ATP形式的能量需求很高。抗癌疗法的发展趋势之一是利用正常细胞和癌细胞代谢的差异。目前构建的基于细胞代谢的疗法集中于尝试以这样的方式重新编程细胞的代谢途径，使得可以停止不受限制的增殖。
In spite of the continuous improvement in our knowledge of the nature of cancer, the causes of its formation and the development of new treatment methods, our knowledge is still incomplete. A key issue is the difference in metabolism between normal and cancer cells. The features that distinguish cancer cells from normal cells are the increased proliferation and abnormal differentiation and maturation of these cells, which are due to regulatory changes in the emerging tumour. Normal cells use oxidative phosphorylation (OXPHOS) in the mitochondrion as a major source of energy during division. During OXPHOS, there are 36 ATP molecules produced from one molecule of glucose, in contrast to glycolysis which provides an ATP supply of only two molecules. Although aerobic glucose metabolism is more efficient, metabolism based on intensive glycolysis provides intermediate metabolites necessary for the synthesis of nucleic acids, proteins and lipids, which are in constant high demand due to the intense cell division in cancer. This is the main reason why the cancer cell does not “give up” on glycolysis despite the high demand for energy in the form of ATP. One of the evolving trends in the development of anti-cancer therapies is to exploit differences in the metabolism of normal cells and cancer cells. Currently constructed therapies, based on cell metabolism, focus on the attempt to reprogram the metabolic pathways of the cell in such a manner that it becomes possible to stop unrestrained proliferation.
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影响因子：
3.4
作者：
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影响因子：
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