Vitamin C prevents hyperoxia-mediated coronary vasoconstriction and impairment of myocardial function in healthy subjects.
Vitamin C prevents hyperoxia-mediated coronary vasoconstriction and impairment of myocardial function in healthy subjects.
复制标题
DOI：
10.1007/s00421-011-1997-x
复制
发表时间：
2012-02
影响因子：
3
通讯作者：
Sinoway, Lawrence I.
中科院分区：
文献类型：
--
作者：
Gao, Zhaohui;Spilk, Samson;Momen, Afsana;Muller, Matthew D.;Leuenberger, Urs A.;Sinoway, Lawrence I.
在当前的医疗实践中，通常给予补充氧气。近年来研究表明，高氧可引起急性氧化应激，并使缺血性心脏病患者的冠状动脉阻力发生迅速而实质性的变化。在这份报告中，我们研究了高氧对冠状动脉血流速度（CBV）的影响是否与心肌功能下降有关。我们也有兴趣确定是否可以通过静脉注射维生素C（一种有效的急性抗氧化剂）逆转组织多普勒成像（TDI）观察到的左心室（LV）功能的假设变化。在高氧之前和之后以及输注和不输注维生素C的情况下，通过经胸超声心动图和TDI测定了八名健康受试者的左心室功能。与室内空气相比，高氧使CBV迅速降低28 ± 3%（从23.50 ± 2.31 cm/s降至17.00 ± 1.79 cm/s），并使相对冠状动脉阻力增加34 ± 5%（从5.63 ± 0.88升至7.32 ± 0.94）。左室心肌收缩期速度降低11 ± 6%（TDI）。这些对血流和功能的影响可通过输注维生素C消除。这表明，这些变化是由维生素C可淬灭物质介导的冠状动脉微循环。
Supplementary oxygen is commonly administered in current medical practice. Recently it has been suggested that hyperoxia causes acute oxidative stress and produces prompt and substantial changes in coronary resistance in patients with ischemic heart disease. In this report, we examined whether the effects of hyperoxia on coronary blood velocity (CBV) would be associated with a reduction in myocardial function. We were also interested in determining if the postulated changes in left ventricular (LV) function seen with Tissue Doppler Imaging (TDI) could be reversed with intravenous vitamin C, a potent, acute anti-oxidant. LV function was determined in eight healthy subjects with transthoracic echocardiography and TDI before and after hyperoxia and with and without infusing vitamin C. Hyperoxia compared to room air promptly reduced CBV by 28 ± 3% (from 23.50 ± 2.31 cm/s down to 17.00 ± 1.79 cm/s) and increased relative coronary resistance by 34 ± 5% (from 5.63 ± 0.88 up to 7.32 ± 0.94). Meanwhile, LV myocardial systolic velocity decreased by 11 ± 6% (TDI). These effects on flow and function were eliminated by the infusion of vitamin C. This suggests that these changes are mediated by vitamin C-quenchable substances acting on the coronary microcirculation.
登录
查看更多内容
DOI：
10.1152/ajpheart.00148.2004
发表时间：
2004-10-01
影响因子：
4.8
作者：
Bailey, DM;Young, IS;Richardson, RS
通讯作者：
Richardson, RS
影响因子：
9.6
作者：
Mak, S;Azevedo, ER;Newton, GE
通讯作者：
Newton, GE
影响因子：
64.8
作者：
Jia, L;Bonaventura, C;Stamler, JS
通讯作者：
Stamler, JS
影响因子：
1.9
作者：
Giakoumis, Anastasios;Berdoukas, Vasilis;Aessopos, Athanassios
通讯作者：
Aessopos, Athanassios
DOI：
10.1016/0735-1097(95)00474-2
发表时间：
1996-02-01
影响因子：
24
作者：
Haque, WA;Boehmer, J;Sinoway, LI
通讯作者：
Sinoway, LI