The Cryptococcus neoformans Titan Cell: From In Vivo Phenomenon to In Vitro Model
The Cryptococcus neoformans Titan Cell: From In Vivo Phenomenon to In Vitro Model
复制标题
新型隐球菌泰坦细胞：从体内现象到体外模型
DOI：
10.1007/s40588-018-0107-9
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发表时间：
2018
影响因子：
5.2
通讯作者：
Elizabeth R. Ballou
中科院分区：
文献类型：
--
作者：
Xin Zhou;Elizabeth R. Ballou
在感染过程中，人类真菌病原体新型隐球菌经历了一个不寻常的变化，从小的单倍体酵母大多倍体泰坦细胞。这种转变现在被公认为是一种毒力因子，但关于钛化是如何调节的以及它如何影响疾病进展的重要问题仍然存在。进展一直受到阻碍的酵母到泰坦过渡，一个挑战，最近克服了三个独立groups.Recent FindingsHere的体外模型的缺乏，我们审查Titanization在患者样本和动物模型的背景下，并设置阶段为三个新的报告描述在体外泰坦细胞诱导试验。我们比较和对比关键的研究结果，把它们放在更广泛的研究背景下，并确定进一步interests.SummaryNew在体外模型领域将允许紧迫的问题，驱动酵母到泰坦过渡的分子机制和它们对耐药性和发病机制的影响得到解决。
Purpose of ReviewDuring infection, the human fungal pathogen Cryptococcus neoformans undergoes an unusual change in size, from small haploid yeast to large polyploid Titan cells. This transition is now well recognized as a virulence factor, but significant questions remain about how Titanisation is regulated and how it influences disease progression. Progress has been impeded by the lack of an in vitro model for the yeast-to-Titan transition, a challenge that was recently overcome by three independent groups.Recent FindingsHere, we review Titanization in the context of patient samples and animal models and set the stage for three new reports describing in vitro Titan cell induction assays. We compare and contrast key findings, place them in the broader research context, and identify areas of further interest.SummaryNew in vitro models will allow pressing questions about molecular mechanisms driving the yeast-to-Titan transition and their influence on drug resistance and pathogenesis to be addressed.
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影响因子：
6.7
作者：
I. Dambuza;Thomas A. Drake;A. Chapuis;L. Taylor-Smith;Nathalie M. Legrave;T. Rasmussen;M. Fisher;T. Bicanic;T. Harrison;M. Jaspars;R. May;Gordon D. Brown;R. Yuecel;D. MacCallum;Elizabeth R. Ballou
通讯作者：
I. Dambuza;Thomas A. Drake;A. Chapuis;L. Taylor-Smith;Nathalie M. Legrave;T. Rasmussen;M. Fisher;T. Bicanic;T. Harrison;M. Jaspars;R. May;Gordon D. Brown;R. Yuecel;D. MacCallum;Elizabeth R. Ballou
影响因子：
30.3
作者：
Homer CM;Summers DK;Goranov AI;Clarke SC;Wiesner DL;Diedrich JK;Moresco JJ;Toffaletti D;Upadhya R;Caradonna I;Petnic S;Pessino V;Cuomo CA;Lodge JK;Perfect J;Yates JR 3rd;Nielsen K;Craik CS;Madhani HD
通讯作者：
Madhani HD
影响因子：
6.4
作者：
Chen Y;Toffaletti DL;Tenor JL;Litvintseva AP;Fang C;Mitchell TG;McDonald TR;Nielsen K;Boulware DR;Bicanic T;Perfect JR
通讯作者：
Perfect JR
影响因子：
5.4
作者：
Zaragoza O;Nielsen K
通讯作者：
Nielsen K
DOI：
10.1016/s1473-3099(17)30243-8
发表时间：
2017-08
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Rajasingham R;Smith RM;Park BJ;Jarvis JN;Govender NP;Chiller TM;Denning DW;Loyse A;Boulware DR
通讯作者：
Boulware DR